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Merck
CN

39205

Dimethylaminomethyl-polystyrene

200-400 mesh particle size, extent of labeling: 3-4 mmol/g base loading, matrix crosslinked with 2% DVB

Synonym(s):

Benzyldimethylamine polymer-bound, Copolymer of styrene and divinylbenzene, dimethylaminomethylated, Polystyrene crosslinked with divinylbenzene, dimethylaminomethylated

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About This Item

Linear Formula:
CH2N(CH3)2 - [CH2CH(C6H55)]n
UNSPSC Code:
12352209
NACRES:
NA.22
MDL number:
MFCD00144140

Key Documents

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SMILES string

[X]C(CC(CC(C[X])c3ccc(cc3)CN(C)C)c2ccc(cc2)CN(C)C)c1ccc(cc1)CN(C)C

reaction suitability

reaction type: solution phase peptide synthesis, reactivity: proton reactive

extent of labeling

3-4 mmol/g base loading

impurities

≤0.5 mmol/g Cl- (resin)

matrix

crosslinked with 2% DVB

particle size

200-400 mesh

General description

Dimethylaminomethyl-polystyrene, also known as benzyldimethylamine, is a polystyrene-supported resin crosslinked with divinylbenzene that is commonly used in solution phase peptide synthesis.

Application

Dimethylaminomethyl-polystyrene is used as a resin to synthesize hydrophobic dipeptides such as bis-phenylalanines that can be used in the study of peptide and protein aggregation. Additionally, it can also be utilized for neutralizing acidic solution in a reaction mixture due to its proton reactive nature.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
011042/1
11042/1
36374/1
036374/1

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Synthesis and properties of new nucleotide analogues possessing squaramide moieties as new phosphate isosters
K Seio
European Journal of Organic Chemistry (2005)
Synthesis of bis-Phenylalanine, A Novel Eight-Membered Cyclic Dipeptide
BV Falcone
Synthetic Communications, 38, 411-418 (2008)

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