39410
4-(Dimethylamino)pyridine, polymer-bound
extent of labeling: ~3.0 mmol/g "DMAP" loading, matrix crosslinked with 2% DVB
Synonym(s):
4-(Dimethylamino)pyridine on Polystyrene, DMAP on PS, polymer bound DMAP
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About This Item
Empirical Formula (Hill Notation):
C8H8
CAS Number:
Molecular Weight:
104.15
UNSPSC Code:
12352128
PubChem Substance ID:
NACRES:
NA.22
MDL number:
reaction suitability
reaction type: solution phase peptide synthesis
Quality Segment
extent of labeling
~3.0 mmol/g "DMAP" loading
matrix
crosslinked with 2% DVB
anion traces
chloride (Cl-): ≤5000 mg/kg
General description
Polymer-bound 4-(dimethylamino)pyridine is used for improved derivatization of chiral and achiral aliphatic amines, amino alcohols and amino acids.
Application
Polymer-bound 4-(dimethylamino)pyridine is used as a supported base in the Michael addition and nitrous acid elimination process step involved in the synthesis of thiophene-2-carboxylates using β-nitroacrylates as starting materials, under a general and efficient continuous flow-based protocol. It also serves as a supported catalyst in the preparation of ω-nitro esters starting from cyclic 2-nitro ketones under solid heterogeneous catalysis.(5)
Other Notes
Polymer supported, recyclable acylation catalyst
Polymer supported, recyclable acylation catalystcitationcitationcitation
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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