396265
Bis(2-carboxyethylgermanium(IV) sesquioxide)
99%
Synonym(s):
GE 132
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About This Item
Linear Formula:
O[Ge(=O)CH2CH2CO2H]2
CAS Number:
Molecular Weight:
339.42
EC Number:
MDL number:
UNSPSC Code:
12352103
PubChem Substance ID:
NACRES:
NA.22
Quality Level
Assay
99%
form
solid
functional group
carboxylic acid
SMILES string
OC(=O)CC[Ge](=O)O[Ge](=O)CCC(O)=O
InChI
1S/C6H10Ge2O7/c9-5(10)1-3-7(13)15-8(14)4-2-6(11)12/h1-4H2,(H,9,10)(H,11,12)
InChI key
XEABSBMNTNXEJM-UHFFFAOYSA-N
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General description
Bis(2-carboxyethylgermanium(IV) sesquioxide), also known as repagermanium, is a water-soluble organogermanium compound that exhibits immunostimulatory properties. It is also used as an ingredient in food and cosmetics.
Application
Bis(2-carboxyethylgermanium(IV) sesquioxide) can be used as a precursor in the preparation of photoluminescent carbon dots, applicable as fluorescent probes in bioimaging applications.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Bonnie J Kaplan et al.
Journal of alternative and complementary medicine (New York, N.Y.), 10(2), 345-348 (2004-05-29)
The preceding paper reviewed the anticancer properties and safety of bis (2-carboxyethylgermanium) sesquioxide (CEGS). An examination of those data leads one to question why this information has not stimulated clinical trials in patients with cancer. The answer is discussed in
Tomoya Yamashita et al.
Arteriosclerosis, thrombosis, and vascular biology, 22(6), 969-974 (2002-06-18)
Monocyte chemoattractant protein-1 (MCP-1), which binds to C-C chemokine receptor 2, has been implicated as the primary source of monocyte chemoattractant function in the early stages of atherosclerosis. Recently, propagermanium, a drug used clinically for the treatment of chronic hepatitis
Kana Tsukuda et al.
Biochemical and biophysical research communications, 409(2), 275-279 (2011-05-18)
Angiotensin II type 1 (AT(1)) receptor blockers (ARBs) are known to prevent the onset of stroke and to attenuate neural damage. Additional beneficial effects of ARBs, independent of AT(1) receptor blockade, have been highlighted. Irbesartan is reported to act as
Boryana Konstantinova Popivanova et al.
Cancer research, 69(19), 7884-7892 (2009-09-24)
Accumulating evidence indicates the crucial contribution of chronic inflammation to various types of carcinogenesis, including colon carcinoma associated with ulcerative colitis and asbestosis-induced malignant mesothelioma. Ulcerative colitis-associated colon carcinogenesis can be recapitulated in mice by azoxymethane administration followed by repetitive
Chisato Hirayama et al.
Journal of gastroenterology, 38(6), 525-532 (2003-06-26)
Although antiviral agents have been adopted for the management of chronic hepatitis B, they have only limited efficacy because of the underlying impaired immune status. Propagermanium, a hydrophilic polymer of 3-oxygermyl propionate, has been reported to have potent immune modulatory
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