396265
Bis(2-carboxyethylgermanium(IV) sesquioxide)
99%
Synonym(s):
GE 132
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About This Item
Linear Formula:
O[Ge(=O)CH2CH2CO2H]2
CAS Number:
Molecular Weight:
339.42
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352103
EC Number:
235-800-0
MDL number:
InChI key
XEABSBMNTNXEJM-UHFFFAOYSA-N
InChI
1S/C6H10Ge2O7/c9-5(10)1-3-7(13)15-8(14)4-2-6(11)12/h1-4H2,(H,9,10)(H,11,12)
SMILES string
OC(=O)CC[Ge](=O)O[Ge](=O)CCC(O)=O
assay
99%
form
solid
functional group
carboxylic acid
Quality Level
General description
Bis(2-carboxyethylgermanium(IV) sesquioxide), also known as repagermanium, is a water-soluble organogermanium compound that exhibits immunostimulatory properties. It is also used as an ingredient in food and cosmetics.
Application
Bis(2-carboxyethylgermanium(IV) sesquioxide) can be used as a precursor in the preparation of photoluminescent carbon dots, applicable as fluorescent probes in bioimaging applications.
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Tomoya Takeda et al.
Scientific reports, 9(1), 13637-13637 (2019-09-22)
Reactive oxygen species (ROS) are very harmful to dermal cells, and it is thus important to develop cosmetics that protect the skin from ROS and other stimuli. Repagermanium is a synthetic water-soluble organogermanium polymer, and in this study, we attempted
Michael Gliem et al.
Annals of neurology, 71(6), 743-752 (2012-06-22)
Inflammation is increasingly viewed as a new therapeutic target in subacute stages of brain infarction. However, apart from causing secondary damage, inflammation could equally promote beneficial lesion remodeling and repair. Distinct subpopulations of monocytes/macrophages (MOs/MPs) may critically determine the outcome
Chisato Hirayama et al.
Journal of gastroenterology, 38(6), 525-532 (2003-06-26)
Although antiviral agents have been adopted for the management of chronic hepatitis B, they have only limited efficacy because of the underlying impaired immune status. Propagermanium, a hydrophilic polymer of 3-oxygermyl propionate, has been reported to have potent immune modulatory
Boryana Konstantinova Popivanova et al.
Cancer research, 69(19), 7884-7892 (2009-09-24)
Accumulating evidence indicates the crucial contribution of chronic inflammation to various types of carcinogenesis, including colon carcinoma associated with ulcerative colitis and asbestosis-induced malignant mesothelioma. Ulcerative colitis-associated colon carcinogenesis can be recapitulated in mice by azoxymethane administration followed by repetitive
Yasuhiro Eto et al.
Journal of cardiovascular pharmacology, 41(2), 171-177 (2003-01-28)
Macrophages play an important role in the pathogenesis of atherosclerosis, for which monocyte chemoattractant protein (MCP)-1 and CCR2 chemokine receptors may be involved. The authors have recently demonstrated that propagermanium exerts inhibitory effect on the CCR2 receptors. In the current
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