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Merck
CN

402184

6-Chloro-3-formyl-7-methylchromone

98%

Synonym(s):

6-Chloro-7-methyl-4-oxo-4H-1-benzopyran-3-carboxaldehyde

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About This Item

Empirical Formula (Hill Notation):
C11H7ClO3
CAS Number:
64481-12-5
Molecular Weight:
222.62
NACRES:
NA.22
PubChem Substance ID:
24865058
UNSPSC Code:
12352100
MDL number:
MFCD00191919
Assay:
98%

Key Documents

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Product Name

6-Chloro-3-formyl-7-methylchromone, 98%

InChI

1S/C11H7ClO3/c1-6-2-10-8(3-9(6)12)11(14)7(4-13)5-15-10/h2-5H,1H3

SMILES string

Cc1cc2OC=C(C=O)C(=O)c2cc1Cl

InChI key

NULJNFUEBPQUNB-UHFFFAOYSA-N

assay

98%

mp

183-185 °C (lit.)

functional group

aldehyde
chloro
ketone

Gene Information

human ... PTPN1(5770)

Application

6-Chloro-3-formyl-7-methylchromone is the suitable reagent used in a study to investigate the multidrug resistabnce reversal by some 3- formylchromones in human colon cancer and mouse lymphoma cells transfected with the human MDR1 gene. It is the suitable reagent used in the synthesis of uridine-based library.

General description

6-Chloro-3-formyl-7-methylchromone (6-Chloro-7-methyl-4-oxo-4H-1-benzopyran-3-carboxaldehyde) is a benzopyran derivative. It is a bicyclic heterocyclic molecule made up of a benzene ring fused to a heterocyclic pyran ring.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
06315MF
01304BS
10927DU
06120CA

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Howard C Hang et al.
Chemistry & biology, 11(3), 337-345 (2004-05-05)
The polypeptide N-acetyl-alpha-galactosaminyltransferases (ppGalNAcTs, also abbreviated ppGaNTases) initiate mucin-type O-linked glycosylation and therefore play pivotal roles in cell-cell communication and protection of tissues. In order to develop new tools for studying mucin-type O-linked glycosylation, we screened a 1338 member uridine-based
Zoltán Baráth et al.
In vivo (Athens, Greece), 20(5), 645-649 (2006-11-10)
Several new 3-formylchromone derivatives proved to be modifiers of multidrug resistance in mouse lymphoma cells and in human Colo320 colon cancer cells. There is apparently a structure-activity relationship between the antiproliferative multidrug resistance-reversing effect and the chemical structure of the
Juan Zhang et al.
The Analyst, 140(16), 5716-5723 (2015-07-15)
Inhibitors of protein tyrosine phosphatase 1B (PTP1B) are promising agents for the treatment of type 2 diabetes and obesity, so a colorimetric method has been developed in this work for PTP1B assay and screening of its inhibitors. The method is

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