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About This Item
Linear Formula:
H2C=C(CH3)CONH(CH2)3N(CH3)2
CAS Number:
Molecular Weight:
170.25
EC Number:
MDL number:
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.23
Quality Level
description
contains: ~650ppm MEHQ as inhibitor
Assay
99%
form
viscous liquid
refractive index
n20/D 1.479 (lit.)
bp
134 °C/2 mmHg (lit.)
density
0.94 g/mL at 25 °C (lit.)
SMILES string
CN(C)CCCNC(=O)C(C)=C
InChI
1S/C9H18N2O/c1-8(2)9(12)10-6-5-7-11(3)4/h1,5-7H2,2-4H3,(H,10,12)
InChI key
GDFCSMCGLZFNFY-UHFFFAOYSA-N
Related Categories
General description
N-[3-(Dimethylamino)propyl]Methacrylamide (DMAPMA) is a water-soluble methacrylamide monomer. It is highly reactive and can undergo radical polymerization and cross-linking reactions. The presence of methylamino group (-N(CH3)2) provides pH responsiveness and hydrophilicity to the resulting polymers. This versatile monomer can be used in drug delivery systems, gene delivery, responsive materials, biocompatible coatings, adhesives, and biomedical engineering.
Application
- Glucose-containing diblock polycations exhibit molecular weight, charge, and cell-type dependence for pDNA delivery.: This study investigates the use of glucose-containing diblock polycations, including N-[3-(Dimethylamino)propyl]methacrylamide, in pDNA delivery systems. The research demonstrates that the efficiency of pDNA delivery is influenced by the molecular weight and charge of the polycations, as well as the type of cell used. This highlights the potential for tailored gene delivery applications in different cell types, emphasizing the role of N-[3-(Dimethylamino)propyl]methacrylamide in creating biocompatible and effective delivery vectors (Wu et al., 2014).
N-[3-(Dimethylamino)propyl]Methacrylamide can be used:
- As a monomer to synthesize self-healing pH-responsive P(DMAPMA-stat-DAA) hydrogels for drug delivery applications.
- As a cationic monomer to develop gene delivery vector due to its ability to complex with nucleic acids and facilitate their intracellular delivery.
- To fabricate iron oxide nanoparticle formulations for 3D printing. These iron inks are utilized for printing magnetic devices, MRI contrast agents for bioimaging and targeted drug delivery systems.
- To prepare a non-toxic synthetic flocculant for harvesting microalgae.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
264.2 °F - closed cup
Flash Point(C)
129 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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