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Merck
CN

41661

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone

absolute, over molecular sieve (H2O ≤0.05%), ≥99.0% (GC)

Synonym(s):

1,3-Dimethyl-2-oxohexahydropyrimidine, N,N′-Dimethylpropylene urea, DMPU

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About This Item

Empirical Formula (Hill Notation):
C6H12N2O
CAS Number:
7226-23-5
Molecular Weight:
128.17
UNSPSC Code:
12352115
NACRES:
NA.22
PubChem Substance ID:
57650056
EC Number:
230-625-6
Beilstein/REAXYS Number:
110562
MDL number:
MFCD00006550
Assay:
≥99.0% (GC)
Form:
liquid

Key Documents

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Product Name

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone, absolute, over molecular sieve (H2O ≤0.05%), ≥99.0% (GC)

InChI key

GUVUOGQBMYCBQP-UHFFFAOYSA-N

InChI

1S/C6H12N2O/c1-7-4-3-5-8(2)6(7)9/h3-5H2,1-2H3

SMILES string

CN1CCCN(C)C1=O

grade

absolute

assay

≥99.0% (GC)

form

liquid

quality

over molecular sieve (H2O ≤0.05%)

refractive index

n20/D 1.488 (lit.)
n20/D 1.489

bp

146 °C/44 mmHg (lit.)

density

1.06 g/mL at 25 °C (lit.)

Quality Level

200

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Application

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone (DMPU) can be used as a:
  • Solvent in the synthesis of 1-aryl-3,4,5-substituted pyrazoles by cyclocondensation of 1,3-diketones with arylhydrazine hydrochlorides.
  • Chelating solvent in the trifluoromethylation of activated and non-activated halogenated double bonds.
  • Ligand in ortho-alkylation of secondary benzamide catalyzed by cobalt.

Other Notes

Aprotic, dipolar solvent, which is an excellent replacement of the carcinogenic HMPA as cosolvent for highly reactive nucleophiles and bases. High Z-selectivity in enolate formation; DMPU was shown to be non-mutagenic and safe.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 2

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

249.8 °F - closed cup

flash_point_c

121 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
SDBB3022
STBL0315
STBK6699
STBK3475
0000125419

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Cobalt-catalyzed ortho-alkylation of secondary benzamide with alkyl chloride through directed C- H bond activation.
Chen Q, et al.
Journal of the American Chemical Society, 133(3), 428-429 (2010)
R.E. Ireland et al.
The Journal of Organic Chemistry, 56, 650-650 (1991)
D. Seebach et al.
Helvetica Chimica Acta, 65, 1101-1101 (1982)
Efficient Trifluoromethylation of Activated and Non-Activated Alkenyl Halides by Using (Trifluoromethyl) trimethylsilane.
Hafner A and Braese S
advanced synthesis and catalysis, 353(16), 3044-3048 (2011)
Efficient Trifluoromethylation of Activated and Non-Activated Alkenyl Halides by Using (Trifluoromethyl) trimethylsilane.
Hafner A and Braese S
Advanced Synthesis & Catalysis, 353(16), 3044-3048 (2011)
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