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Merck
CN

420107

Sigma-Aldrich

Bromotris(dimethylamino)phosphonium hexafluorophosphate

98%

Synonym(s):

BroP, Bromotris(N-methylmethanaminato)-phosphorus hexafluorophosphate

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About This Item

Linear Formula:
BrP[N(CH3)2]3PF6
CAS Number:
50296-37-2
Molecular Weight:
388.07
MDL number:
MFCD00191864
UNSPSC Code:
12352101
PubChem Substance ID:
24866311

Key Documents

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Assay

98%

reaction suitability

reaction type: Coupling Reactions

mp

>300 °C (lit.)

application(s)

peptide synthesis

SMILES string

F[P-](F)(F)(F)(F)F.CN(C)[P+](Br)(N(C)C)N(C)C

InChI

1S/C6H18BrN3P.F6P/c1-8(2)11(7,9(3)4)10(5)6;1-7(2,3,4,5)6/h1-6H3;/q+1;-1

InChI key

XELPBWPBGHCIKX-UHFFFAOYSA-N

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Application

Reagent for:
Conjugate addition of nitroalkanes to an acrylate equivalent
A novel polymer supported approach to nucleoside modification
Asymmetric hydrogenations
Peptide coupling
Pyrrolidine hydroxylation
Synthesis of cyclic PNA-based compound directed against HIV-1 TAR RNA

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictograms

Health hazardCorrosion
GHS08,GHS05

Signal Word

Danger

Hazard Statements

H314,H350

Hazard Classifications

Carc. 1B - Skin Corr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
011821/4V
1452305V
1452305
011821/4
09810TC

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A M Senderowicz et al.
Journal of the National Cancer Institute, 87(1), 46-51 (1995-01-04)
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Zizhuo Su et al.
Journal of vascular research, 57(5), 254-260 (2020-06-12)
The exocytosis of cyclophilin A (CyPA) by a vesicular pathway in response to reactive oxygen species has been determined. However, other sources of extracellular CyPA remain obscure. The aim of this study was to determine the role of autophagy in
S C Posey et al.
The Journal of biological chemistry, 274(7), 4259-4265 (1999-02-06)
Participation of the actin cytoskeleton in the transduction of proliferative signals has been established through the use of compounds that disrupt the cytoskeleton. To address the possibility that actin also participates in the transduction of an apoptotic signal, we have
V R Scott et al.
Antimicrobial agents and chemotherapy, 32(8), 1154-1157 (1988-08-01)
Jasplakinolide is a cyclodepsipeptide which represents a new class of antifungal agents with potent activity against Candida albicans. Jasplakinolide is fungicidal against C. albicans with both a MIC and a minimum lethal concentration of 25 micrograms/ml in a broth dilution
J A Rosado et al.
The Journal of biological chemistry, 275(11), 7527-7533 (2000-03-14)
The nature of the mechanism underlying store-mediated Ca(2+) entry has been investigated in human platelets through a combination of cytoskeletal modifications. Inhibition of actin polymerization by cytochalasin D or latrunculin A had a biphasic time-dependent effect on Ca(2+) entry, showing
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