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Merck
CN

435457

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)

average Mn ~4,400

Synonym(s):

Nanopatterning, Pluronic® L-121, block-copolymers, PEG-PPG-PEG

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About This Item

CAS Number:
9003-11-6
UNSPSC Code:
12352112
PubChem Substance ID:
24867235
NACRES:
NA.23
MDL number:
MFCD00082049

Key Documents

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Product Name

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), average Mn ~4,400

SMILES string

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

vapor density

>1 (vs air)

vapor pressure

<0.3 mmHg ( 20 °C)

form

viscous liquid

mol wt

average Mn ~4,400

composition

PEG, 30 wt. %

refractive index

n20/D 1.454

surface tension

33 dyn/cm, 25 °C, 0.1 wt. % in H2O

viscosity

1,200 cP(25 °C, Brookfield)(lit.)

transition temp

cloud point 14 °C (1 wt. % aqueous solution)
softening point 5 °C

density

1.006 g/mL at 25 °C

HLB

1.0 - 7.0

Quality Level

100

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Application

Hard and soft surface cleaners, defoamers in coatings and water treatment. Lubricant in metal working, anti-foaming aid and extender for linear and cross-linked polyesters and polyurethanes.

Features and Benefits

Surface active material whose properties are dependent on the hydrophilic (EO)/hydrophobic (PO) ratio. High EO content gives better o/w stabilizers.

Physical form

Terminal primary dihydroxy-functional oligomer.

Legal Information

Pluronic is a registered trademark of BASF

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKCT9806
MKCQ9637
MKCV4366
MKCQ9874
MKCS4913

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Wei Xu et al.
Drug delivery, 19(4), 208-219 (2012-05-31)
The aim of this study was to construct novel targeting polymeric micelles. Folate-Poly (ethylenimine)-Pluronic copolymers were synthesized. A paclitaxel (PTX)-loaded mixed micelles consisting of Folate-Poly (ethylenimine)-Pluronic and Pluronic L121 copolymers have been developed. The mixed micelles showed nano-sized spherical morphology.
Liyan Zhao et al.
Colloids and surfaces. B, Biointerfaces, 97, 101-108 (2012-05-23)
In this study, curcumin (Cur) loaded mixed micelles (Cur-PF), composed of Pluronic P123 (P123) and Pluronic F68 (F68), was prepared using the thin-film hydration method and evaluated in vitro. The preparation process was optimized with a central composite design (CCD).
A Kiwilsza et al.
Journal of microencapsulation, 30(1), 21-27 (2012-06-09)
Mesoporous material SBA-15 of hexagonal structure was synthesised and its usefulness as a carrier for a poorly soluble drug--lacidipine (LA)--was tested. The source of silica was tetraethyl orthosilicate (TEOS) and the structure ordering agent was non-ionic surfactant Pluronic P123. SBA-15
Houjian Gong et al.
Langmuir : the ACS journal of surfaces and colloids, 28(38), 13590-13600 (2012-09-08)
The block polyethers PEO-PPO-ph-PPO-PEO (BPE) and PPO-PEO-ph-PEO-PPO (BEP) are synthesized by anionic polymerization using bisphenol A as initiator. Compared with Pluronic P123, the aggregation behaviors of BPE and BEP at an air/water interface are investigated by the surface tension and
Neeta Jain-Gupta et al.
FEMS immunology and medical microbiology, 66(3), 436-444 (2012-11-21)
Brucellosis is the most common zoonotic disease worldwide, and there is no vaccine for human use. Brucella melitensis Rev1, a live attenuated strain, is the commercial vaccine for small ruminants to prevent B. melitensis infections but has been associated with abortions
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