437018
N-Boc-1,6-hexanediamine hydrochloride
97%
Synonym(s):
N-Boc-1,6-diamino-hexane hydrochloride, tert-Butyl N-(6-aminohexyl)carbamate hydrochloride
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About This Item
Linear Formula:
(CH3)3COCONH(CH2)6NH2 · HCl
CAS Number:
Molecular Weight:
252.78
UNSPSC Code:
12352116
NACRES:
NA.22
PubChem Substance ID:
EC Number:
265-976-4
Beilstein/REAXYS Number:
3631740
MDL number:
Assay:
97%
Form:
solid
Quality Level
InChI key
JSBWQIZQJOQPFN-UHFFFAOYSA-N
InChI
1S/C11H24N2O2.ClH/c1-11(2,3)15-10(14)13-9-7-5-4-6-8-12;/h4-9,12H2,1-3H3,(H,13,14);1H
SMILES string
NCCCCCCNC(OC(C)(C)C)=O.[H]Cl
assay
97%
form
solid
reaction suitability
reagent type: cross-linking reagent
mp
162-164 °C (lit.)
functional group
Boc, amine
Application
N-Boc-1,6-hexanediamine hydrochloride is a general reagent to introduce a C6-spacer. It can be used in:
- Synthesis of poly(L-glutamic acid) gadolinium chelates as biodegradable MRI contrast agents.
- Synthesis of cholesteryl-functionalized hyaluronic acid-based anionic nanogel for protein delivery.
- Preparation of amphiphilic prodrug, containing anticancer drug chlorambucil, which would self-assemble to form micelles in aqueous solution.
Reagent for the introduction of a C6-spacer.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Rational Design of an Amphiphilic Chlorambucil Prodrug Realizing Self-Assembled Micelles for Efficient Anticancer Therapy.
Hu X, et al.
ACS biomaterials science & engineering, 4(3), 973-980 (2018)
Injectable hydrogel for sustained protein release by salt?induced association of hyaluronic acid nanogel.
Nakai T, et al.
Macromolecular Bioscience, 12(4), 475-483 (2012)
Synthesis and characterization of poly (L-glutamic acid) gadolinium chelate: a new biodegradable MRI contrast agent.
Wen X, et al.
Bioconjugate Chemistry, 15(6), 1408-1415 (2004)
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