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Merck
CN

437352

4-(1-Pyrrolidinyl)piperidine

95%

Synonym(s):

1-(Piperidin-4-yl)pyrrolidine

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About This Item

Empirical Formula (Hill Notation):
C9H18N2
CAS Number:
Molecular Weight:
154.25
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
225-676-6
MDL number:
Assay:
95%
Form:
solid
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assay

95%

form

solid

mp

53-56 °C (lit.)

SMILES string

C1CCN(C1)C2CCNCC2

InChI

1S/C9H18N2/c1-2-8-11(7-1)9-3-5-10-6-4-9/h9-10H,1-8H2

InChI key

STWODXDTKGTVCJ-UHFFFAOYSA-N

General description

4-(1-Pyrrolidinyl)piperidine (4-pypp) has been reported to form Hofmann type complexes [M(4-pypp)2Ni(CN)4] (M=Ni or Co) and their FT-IR and Raman spectra have been studied. FT-IR, Raman spectra and the vibrational spectra of 4-pypp have been recorded between 4000 and 400cm-1.

Application

4-(1-Pyrrolidinyl)piperidine was employed for the synthesis of the following analogs:
  • 4-pyrrolidin-1´-yl-1-[2-(2″-nitro-phenyl)-2-oxo-ethyl]-piperidinium bromide
  • 4-pyrrolidin-1´-yl-1-[2-(3″-nitro-phenyl)-2-oxo-ethyl]-piperidinium bromide
  • 4-pyrrolidin-1´-yl-1-[2-(2″,4″-dimethoxy-phenyl)-2-oxo-ethyl]-piperidinium bromide
  • 4-pyrrolidin-1´-yl-1-[2-(3″,4″-dihydroxy-phenyl)-2-oxo-ethyl]-piperidinium bromide
Reactant for synthesis of:
Small molecule ligands of methyl-lysine binding proteins
Small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells
Selective Polo-like kinase 1 inhibitors
Molecules with effects on plasma glucose levels
Vasopressin1b receptor antagonists
IKKβ inhibitors


pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves



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