(3-Chloropropyl)trimethoxysilane

(3-Chloropropyl)trimethoxysilane (CPTMS) is an organo-silane which forms a self-assembled monolayer (SAMs) that facilitates the surface modification of different bio-and nano- materials.

CPTMS can be used to silanize a variety of nanoparticles like carbon nanotubes (CNT) and silica nanoparticles (SiO₂) for different applications like development for molecularly imprinted polymers for protein detection and fabrication of mesoporous silica(organic-inorganic hybrid). It may be used to functionalize silica-iron oxide nanoparticles which can be used as catalysts for the synthesis of pyrano(3,2−c:5,6−c′)dichromene-6,8-dione derivatives.

(3-Chloropropyl)trimethoxysilane may be used in the synthesis of octakis(3-chloropropyl)octasilsesquioxane.{35}