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440191

Hexamethyldisilazane

reagent grade, ≥99%

Synonym(s):

Bis(trimethylsilyl)amine, HMDS

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About This Item

Linear Formula:
(CH3)3SiNHSi(CH3)3
CAS Number:
999-97-3
Molecular Weight:
161.39
UNSPSC Code:
12352103
NACRES:
NA.23
PubChem Substance ID:
24867576
EC Number:
213-668-5
Beilstein/REAXYS Number:
635752
MDL number:
MFCD00008259
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grade

reagent grade

Quality Segment

300

assay

≥99%

form

liquid

refractive index

n20/D 1.407 (lit.)

bp

125 °C (lit.)

SMILES string

C[Si](C)(C)N[Si](C)(C)C

InChI

1S/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3

InChI key

FFUAGWLWBBFQJT-UHFFFAOYSA-N

General description

Hexamethyldisilane (HMDS) is a stable and effectivereagent for trimethylsilylation of hydrogen-labile substrates such as alcohols,amines, and carboxylic acids. It is commonly used for the protection of sensitivefunctional groups during chemical synthesis. Owing to its low cost, high vapor pressure, and safety, itis widely used as a precursor in chemical vapor deposition(CVD) reactions.

Application

Hexamethyldisilane (HMDS) can be used:
  • As a silylating agent in the trimethylsilylation of alcohols under nearly neutral reaction conditions.
  • To control the molecular weights of polypeptides during ring-opening polymerization of α-amino acid N-carboxyanhydrides.
  • To fabricate silicon carbonitride thin films by plasma-enhanced CVD.
  • For specimen preparation for scanning electron microscopy and the preparation of trimethylsilyl ethers from hydroxy compounds.

Features and Benefits

  • High chemicalstability and low molecular weight
  • Nontoxic andcost-effective reagent
  • Ammonia is theonly byproduct generated during silylation
  • Silylationreaction using HDMS is nearly neutral and does not need any precaution

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pictograms

FlameSkull and crossbones
GHS02,GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

52.5 °F - closed cup

flash_point_c

11.4 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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