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Sigma-Aldrich

Coumarin 6

98%

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Synonym(s):
3-(2-Benzothiazolyl)-7-(diethylamino)coumarin, 3-(2-Benzothiazolyl)-N,N-diethylumbelliferylamine
Empirical Formula (Hill Notation):
C20H18N2O2S
CAS Number:
38215-36-0
Molecular Weight:
350.43
Beilstein:
1085798
EC Number:
253-830-2
MDL number:
MFCD00041869
PubChem Substance ID:
24867935
NACRES:
NA.23

Quality Level

100

Assay

98%

form

solid

mp

208-210 °C (lit.)

λmax

444 nm

fluorescence

λem 505 nm in ethanol (Lasing peak 534 nm, lasing range 515 - 558 nm (DMSO), pump source XeCl (308 nm))

OLED Device Performance

ITO/Alq3:Coumarin 6/Mg:Ag

  • Color: green
  • Max. EQE: 2.5 %

SMILES string

CCN(CC)c1ccc2C=C(C(=O)Oc2c1)c3nc4ccccc4s3

InChI

1S/C20H18N2O2S/c1-3-22(4-2)14-10-9-13-11-15(20(23)24-17(13)12-14)19-21-16-7-5-6-8-18(16)25-19/h5-12H,3-4H2,1-2H3

InChI key

VBVAVBCYMYWNOU-UHFFFAOYSA-N

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General description

Coumarin 6 (C6) is a derivative of coumarin with a benzothiazolyl group at the position 3. It emits fluorescence in solid and solution state and is used as fluorescent dye to stain organelles. C6 is majorly used as blue-green spectrum laser dye and is microenvironment sensitive.
Coumarin 6 is a fluorescent dye that belongs to the 7-diethylaminocoumarin series that can be used in a variety of biological activities. It can be used as a dopant that exhibits green light (500 nm) in optoelectronic applications.

Application

Coumarin 6 dye can be used in the labeling and visualization of polymeric nanoparticles in biological applications, such as oral drug delivery systems for cancer. It can also be used in development of electroluminescent devices such as organic light emitting diodes (OLEDs).
Coumarin 6 has been used as a hydrophobic fluorescent dye
  • in block copolymer (BCP)-based micelle based drug delivery studies in glioma cell lines
  • in combination with flufenamic acid (FA) based nanoprodrug uptake in glioma cells
  • in poly(lactic-co-glycolic acid) (PLGA) based elvitegravir nanoprodrug uptake studies

Laser dye

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Seungil Kim et al.
Journal of biomaterials science. Polymer edition, 28(17), 2082-2099 (2017-08-31)
New amphiphilic PEGylated poly(aspartic acid) graft copolymer (PASP-PEG-Ph) was synthesized as a nanocarrier for intravaginal drug delivery of poorly water-soluble drugs. PASP-PEG-Ph self-assembled into negatively charged spherically shaped nanoparticles in the presence of pH 4.5 and pH 7.0 vaginal fluid
Micelle-templated, poly (lactic-co-glycolic acid) nanoparticles for hydrophobic drug delivery
Nabar GM, et al.
International journal of nanomedicine, 13, 351-351 (2018)
Solvent effects on emission yield and lifetime for coumarin laser dyes. Requirements for a rotatory decay mechanism.
Jones G, et al.
The Journal of Physical Chemistry, 89(2), 294-300 (1985)
Characterization of coumarin-6 polycrystalline films growth from vacuum deposition at various substrate temperatures
Chen KL, et al.
Scientific reports, 8(1), 16740-16740 (2018)
Nanoprodrugs of NSAIDs: Preparation and characterization of flufenamic acid nanoprodrugs
Lee BS, et al.
Journal of Drug Delivery, 2011 (2011)
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