44570
Dowtherm® A
eutectic mixture of 26.5% diphenyl + 73.5% diphenyl oxide
Synonym(s):
Diphyl
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About This Item
Quality Segment
refractive index
n20/D 1.590
functional group
phenoxy, phenyl
SMILES string
c1ccc(cc1)-c2ccccc2.O(c3ccccc3)c4ccccc4
InChI
1S/C12H10O.C12H10/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12;1-3-7-11(8-4-1)12-9-5-2-6-10-12/h1-10H;1-10H
InChI key
MHCVCKDNQYMGEX-UHFFFAOYSA-N
General description
Dowtherm® A is a thermally stable organic heat transfer fluid composed of a eutectic mixture of highly stable compounds, biphenyl, and diphenyl oxide. Dowtherm® A is suitable for high-temperature heat transfer applications up to 400 °C. This fluid can be used in both liquid and vapor phase systems.
Application
Dowtherm® A can be used as a high boiling solvent in cyclization reactions. For example, it is used to synthesize:
- 1-Hydroxy-5-methoxy-1,2-dihydrobenzo[f][2,7]naphthyridines from 2-chloro-3-formyl quinolines.
- Isoindolinone derivatives via intramolecular Diels–Alder cycloaddition reactions of substituted pyridazines.
- Phosphorylated azaheterocycles from 2-diethoxyphosphoryl-3-methoxyacrylate via intramolecular cyclizations under thermal conditions.
Legal Information
DOWTHERM is a registered trademark of The Dow Chemical Company or an affiliated company of Dow
signalword
Danger
target_organs
Respiratory system
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
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