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Merck
CN

464643

1-Z-4-Piperidone

99%

Synonym(s):

1-(Benzyloxycarbonyl)-4-piperidinone, 1-Cbz-4-Piperidone, Benzyl 4-oxo-1-piperidinecarboxylate

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About This Item

Empirical Formula (Hill Notation):
C13H15NO3
CAS Number:
Molecular Weight:
233.26
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1533716
Assay:
99%
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assay

99%

refractive index

n20/D 1.542 (lit.)

bp

114-140 °C/0.25 mmHg (lit.)

density

1.172 g/mL at 25 °C (lit.)

functional group

ketone, phenyl

SMILES string

O=C1CCN(CC1)C(=O)OCc2ccccc2

InChI

1S/C13H15NO3/c15-12-6-8-14(9-7-12)13(16)17-10-11-4-2-1-3-5-11/h1-5H,6-10H2

InChI key

VZOVOHRDLOYBJX-UHFFFAOYSA-N



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pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

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Articles

Knoevenagel Condensation is an organic reaction named after Emil Knoevenagel. It is a classic C-C bond formation reaction and a modification of the Aldol Condensation.


Tetrahedron Letters, 42, 6943-6943 (2001)
Yong Huang et al.
Journal of the American Chemical Society, 124(33), 9662-9663 (2002-08-15)
We report the first examples of hydrogen-bond-promoted acceleration of hetero-Diels-Alder reactions and the use of such catalysis for the hetero-Diels-Alder reactions of simple, unactivated ketones. Several spiro-fused dihydropyans were synthesized in good yields using this procedure. This activation protocol represents
Iyassu K Sebhat et al.
Journal of medicinal chemistry, 45(21), 4589-4593 (2002-10-04)
Synthetic and natural peptides that act as nonselective melanocortin receptor agonists have been found to be anorexigenic and to stimulate erectile activity. We report the design and development of 1, a potent, selective (1184-fold vs MC3R, 350-fold vs MC5R), small-molecule



Global Trade Item Number

SKUGTIN
464643-25ML04061838128010
464643-100ML04061838128003
464643-5ML04061838128027