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480142

4-Phenoxyphenylboronic acid

≥95.0%

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About This Item

Linear Formula:
C6H5OC6H4B(OH)2
CAS Number:
51067-38-0
Molecular Weight:
214.02
NACRES:
NA.22
PubChem Substance ID:
24871550
UNSPSC Code:
12352103
MDL number:
MFCD00093312
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Quality Segment

100

assay

≥95.0%

mp

141-145 °C (lit.)

functional group

phenoxy

SMILES string

OB(O)c1ccc(Oc2ccccc2)cc1

InChI

1S/C12H11BO3/c14-13(15)10-6-8-12(9-7-10)16-11-4-2-1-3-5-11/h1-9,14-15H

InChI key

KFXUHRXGLWUOJT-UHFFFAOYSA-N

Application

4-Phenoxyphenylboronic acid can be used as a reactant:
  • In the Suzuki-Miyaura coupling reaction to synthesize aryl derivatives via C-C bond formation by reacting with different aryl halides over a palladium catalyst.
  • To prepare 1-phenoxy-4-(trifluoromethyl)benzene via oxidative trifluoromethylation using Chan-Lam-type reaction conditions.
  • To synthesize evobrutinib, a potent Bruton′s tyrosine kinase (BTK) inhibitor.

Other Notes

Contains varying amounts of anhydride

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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