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480894

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine

Name: <I>O</I>-(Tetrahydro-2<I>H</I>-pyran-2-yl)hydroxylamine
Brand: ALDRICH

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About This Item

Empirical Formula (Hill Notation):

C₅H₁₁NO₂

CAS Number:

6723-30-4

Molecular Weight:

117.15

NACRES:

NA.22

PubChem Substance ID:

24871725

UNSPSC Code:

12352100

MDL number:

MFCD01321374

Assay:

96%

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Properties

Quality Segment

200

assay

96%

bp

81 °C/20 mmHg (lit.)

mp

34-37 °C (lit.)

functional group

ether

SMILES string

NOC1CCCCO1

InChI

1S/C5H11NO2/c6-8-5-3-1-2-4-7-5/h5H,1-4,6H2

InChI key

NLXXVSKHVGDQAT-UHFFFAOYSA-N

Description

General description

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine (OTX) is an O-substituted hydroxylamine. The coupling of OTX with alkaline gel electrophoresis has been reported to improve the process of detecting single strand breaks (SSBs) in DNA.

Application

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine may be used in the synthesis of 2-(5-bromothiophene-2-sulfonamido)-N-(tetrahydro-2H-pyran-2-yloxy)acetamides.
It may be used in the synthesis of the following potential histone deacetylase (HDAC) inhibitors:

2-[1-(naphthalene-2-sulfonyl)-heterocyclyl]-pyrimidine-5-carboxylic acid (tetrahydropyran-2-yloxy)-amides
(E)-3-(2-benzyl-1-oxoisoindolin-6-yl)-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide
3-(1-benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)-N-hydroxy-acrylamide

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

flash_point_f

179.6 °F - closed cup

flash_point_c

82 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

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