498270
1-Chloro-N,N,2-trimethyl-1-propenylamine
96%
Synonym(s):
Ghosez′s reagent
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Linear Formula:
(CH3)2C=C(Cl)N(CH3)2
CAS Number:
Molecular Weight:
133.62
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352302
MDL number:
Assay:
96%
Quality Level
assay
96%
refractive index
n20/D 1.453 (lit.)
bp
129-130 °C (lit.)
density
1.01 g/mL at 25 °C (lit.)
functional group
amine, chloro
storage temp.
2-8°C
SMILES string
CN(C)\C(Cl)=C(\C)C
InChI
1S/C6H12ClN/c1-5(2)6(7)8(3)4/h1-4H3
InChI key
GQIRIWDEZSKOCN-UHFFFAOYSA-N
Application
1-Chloro-N,N,2-trimethyl-1-propenylamine is an acid halogenation reagent developed by Ghosez, that enables the conversion of carboxylic acids into the corresponding chlorides under strictly neutral conditions. This method was successfully used in the total synthesis of caloporoside, roseophilin, (-)-enniatin B, (±)-epimeloscine and (±)-meloscine.
signalword
Danger
Storage Class
3 - Flammable liquids
wgk
WGK 3
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
hcodes
Hazard Classifications
Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B
flash_point_f
<73.4 °F - closed cup
flash_point_c
< 23 °C - closed cup
Regulatory Information
危险化学品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Articles
Fluoroamidinium salts advance acid halogenation with greater stability and no oxazolones conversion compared to chlorides.
H. Bohme and H. G. Viehe, Eds.
Adv. Org. Chem., 9, 421-421 (1976)
A total synthesis of the ammonium ionophore,(?)-enniatin B.
Hu D, et al.
Tetrahedron Letters, 53(32), 4077-4079 (2012)
Total Synthesis of Roseophilin.
Furstner A, et al.
Journal of the American Chemical Society, 120 (12), 2817?2825-2817?2825 (1998)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 498270-5ML | 04061832421780 |
| 498270-50ML | 04061832421773 |
| 498270-250ML | 04061838135711 |