49920
Glycerol formal
≥98.0% (GC)
Synonym(s):
1,3(or 2,3)-O-Methylene-1,2,3-propanetriol
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About This Item
Empirical Formula (Hill Notation):
C4H8O3
CAS Number:
Molecular Weight:
104.10
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
103206
Assay:
≥98.0% (GC)
Quality Level
assay
≥98.0% (GC)
contains
~0.02% 2,6-di-tert-butyl-4-methylphenol as stabilizer
composition
5-hydroxy-1,3-dioxane, ~60% , 4-hydroxymethyl-1,3-dioxolane, ~40%
refractive index
n20/D 1.451
bp
192-193 °C (lit.)
density
1.203 g/mL at 25 °C (lit.)
functional group
ether, hydroxyl
SMILES string
OCC1COCO1.OC2COCOC2
InChI
1S/2C4H8O3/c5-4-1-6-3-7-2-4;5-1-4-2-6-3-7-4/h2*4-5H,1-3H2
InChI key
JIUMSISXCKWZTA-UHFFFAOYSA-N
General description
Glycerol formal (GF) is a light glycerol acetal that is composed of ~60% 5-hydroxy-1,3-dioxane and ~40% 4-hydroxymethyl-1,3-dioxolane. It can be prepared by reacting glycerol and formaldehyde in the presence of acid catalyst. The potential of GF as an injection solvent for use in toxicity testing has been reported.
Application
Glycerol formal may be used in the multi-step synthesis of 9-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl]guanine (2′-nor-2′-deoxyguanosine), an analog of acyclovir. It may be used in the preparation of 4-substituted dioxolanes.
Glycerol formal is used to to solubilize water-insoluble compounds for subsequent aqueous dilution. It has been used as a chemical and dye emulsifier and as a cosolvent for drug delivery
Glycerol formal is used to to solubilize water-insoluble compounds for subsequent aqueous dilution. It has been used as a chemical and dye emulsifier and as a cosolvent for drug delivery. Glycerol formal was used as a vehicle for antibiotic delivery in rats.
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A note on glycerol formal as a solvent in toxicity testing.
Sanderson DM.
The Journal of Pharmacy and Pharmacology, 11(1), 150-156 (1959)
Activation by thymidine kinase and potent antiherpetic activity of 2'-nor-2'-deoxyguanosine (2' NDG).
Ashton WT, et al.
Biochemical and Biophysical Research Communications, 108(4), 1716-1721 (1982)
4-Substituted dioxolanes by chemoselective reactions on glycerol formal.
Gras JL, et al.
Tetrahedron Letters, 34(27), 4335-4336 (1993)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 49920-100ML | 04061832421971 |
| 49920-500ML | 04061832421988 |