Skip to Content
Merck
CN

Key Documents

View All Documentation

49920

Glycerol formal

≥98.0% (GC)

Synonym(s):

1,3(or 2,3)-O-Methylene-1,2,3-propanetriol

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C4H8O3
CAS Number:
99569-11-6
Molecular Weight:
104.10
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
57651229
MDL number:
MFCD10039829
Beilstein/REAXYS Number:
103206
Assay:
≥98.0% (GC)
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Segment

assay

≥98.0% (GC)

contains

~0.02% 2,6-di-tert-butyl-4-methylphenol as stabilizer

composition

5-hydroxy-1,3-dioxane, ~60% , 4-hydroxymethyl-1,3-dioxolane, ~40%

refractive index

n20/D 1.451

bp

192-193 °C (lit.)

density

1.203 g/mL at 25 °C (lit.)

functional group

ether, hydroxyl

SMILES string

OCC1COCO1.OC2COCOC2

InChI

1S/2C4H8O3/c5-4-1-6-3-7-2-4;5-1-4-2-6-3-7-4/h2*4-5H,1-3H2

InChI key

JIUMSISXCKWZTA-UHFFFAOYSA-N

General description

Glycerol formal (GF) is a light glycerol acetal that is composed of ~60% 5-hydroxy-1,3-dioxane and ~40% 4-hydroxymethyl-1,3-dioxolane. It can be prepared by reacting glycerol and formaldehyde in the presence of acid catalyst. The potential of GF as an injection solvent for use in toxicity testing has been reported.

Application

Glycerol formal may be used in the multi-step synthesis of 9-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl]guanine (2′-nor-2′-deoxyguanosine), an analog of acyclovir. It may be used in the preparation of 4-substituted dioxolanes.
Glycerol formal is used to to solubilize water-insoluble compounds for subsequent aqueous dilution. It has been used as a chemical and dye emulsifier and as a cosolvent for drug delivery
Glycerol formal is used to to solubilize water-insoluble compounds for subsequent aqueous dilution. It has been used as a chemical and dye emulsifier and as a cosolvent for drug delivery. Glycerol formal was used as a vehicle for antibiotic delivery in rats.

Still not finding the right product?

Explore all of our products under Glycerol formal

WGK

WGK 3

PPE (personal protective equipment)

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Storage Class

10 - Combustible liquids

Flash Point (°F)

199.4 °F - closed cup

Flash Point (°C)

93 °C - closed cup

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library