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Merck
CN

50515

Stearyl glycyrrhetinate

≥95.0%

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About This Item

Empirical Formula (Hill Notation):
C48H82O4
CAS Number:
13832-70-7
Molecular Weight:
723.16
UNSPSC Code:
12352108
NACRES:
NA.22
PubChem Substance ID:
57651256
EC Number:
419-580-5
Beilstein/REAXYS Number:
7612541
MDL number:
MFCD00674112
Assay:
≥95.0%

Key Documents

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InChI key

WNIFXKPDILJURQ-JKPOUOEOSA-N

InChI

1S/C48H82O4/c1-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-33-52-42(51)45(5)30-29-44(4)31-32-47(7)36(37(44)35-45)34-38(49)41-46(6)27-26-40(50)43(2,3)39(46)25-28-48(41,47)8/h34,37,39-41,50H,9-33,35H2,1-8H3/t37-,39-,40-,41+,44+,45-,46-,47+,48+/m0/s1

SMILES string

CCCCCCCCCCCCCCCCCCOC(=O)[C@@]1(C)CC[C@]2(C)CC[C@]3(C)C(=CC(=O)[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1

assay

≥95.0%

mp

70-77 °C

functional group

ester, hydroxyl, ketone

Quality Level

100

Related Categories

General description

Stearyl glycyrrhetinate is a stearic acid ester of glycyrrhetinic acid, generally used as a flavoring agent in commercially available cosmetic products.

Application

Stearyl glycyrrhetinate can be used to prepare modified liposomes loaded with norcantharidin and 10-hydroxycamptothecin, which are used as drug delivery systems in cancer therapy.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
395380/1

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Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate, Glycyrrhetinyl Stearate, Stearyl Glycyrrhetinate, Glycyrrhizic Acid, Ammonium Glycyrrhizate, Dipotassium
International Journal of Toxicology, 26, 79-79 (2007)
Jing Zhu et al.
Experimental and therapeutic medicine, 16(3), 1639-1646 (2018-09-07)
In the current study, norcantharidin (NCTD)-loaded liposomes (LIPs) modified with stearyl glycyrrhetinate (SG; SG-NCTD-LIP) were prepared by the ethanol injection method. To increase the drug encapsulation efficiency (EE), the formulation of NCTD-LIP was optimized by single factor test and orthogonal
Ting Zhou et al.
Drug delivery, 26(1), 673-679 (2019-07-04)
10-Hydroxycamptothecin (HCPT) liposomes surface modified with stearyl glycyrrhetinate (SG) were prepared by the film dispersion method. Characterization of the liposomes, including drug release in vitro, pharmacokinetics and tissue distribution, was done. HCPT in plasma and tissues was determined by high-performance
Carmelo Puglia et al.
Journal of cosmetic science, 64(5), 341-353 (2013-10-22)
The aim of this study was to assess the ability of some vehicles (emulsion and emulgel), containing hydrogenated lecithin as penetration enhancer, in increasing the percutaneous absorption of the two model compounds dipotassium glycyrrhizinate (DG) and stearyl glycyrrhetinate (SG). Furthermore

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