511781
2,6-Difluorophenyl isothiocyanate
98%
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About This Item
Linear Formula:
F2C6H3NCS
CAS Number:
Molecular Weight:
171.17
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
98%
InChI
1S/C7H3F2NS/c8-5-2-1-3-6(9)7(5)10-4-11/h1-3H
SMILES string
Fc1cccc(F)c1N=C=S
InChI key
DBSXNGIBAKYMSS-UHFFFAOYSA-N
assay
98%
refractive index
n20/D 1.604 (lit.)
bp
217 °C (lit.)
density
1.325 g/mL at 25 °C (lit.)
functional group
fluoro, isothiocyanate
storage temp.
2-8°C
Quality Level
General description
2,6-Difluorophenyl isothiocyanate (1,3-Difluoro-2-isothiocyanatobenzene), an aryl isocyanate, can be prepared from difluoroaniline. 1H-[1,2,4]triazole-3,5-diamine undergoes acylation with 2,6-difluorophenyl isothiocyanate to form the corresponding 1-acyl-1H-[1,2,4]triazole-3,5-diamine.
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Corr. 1B
Storage Class
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
219.2 °F - closed cup
flash_point_c
104 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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J W Tilley et al.
Journal of medicinal chemistry, 23(12), 1387-1392 (1980-12-01)
Structure-activity studies were carried out on a series of antihypertensive 1-(2-aminoethyl)-3-(substituted phenyl)thioureas. From this class of compounds, the 2,6-dichlorophenyl analogue 2 was found to have potent oral antihypertensive activity in two hypertensive rat models and the renal hypertensive dog. In
1-Acyl-1H-[1,2,4] triazole-3,5-diamine Analogues as Novel and Potent Anticancer Cyclin-Dependent Kinase Inhibitors: Synthesis and Evaluation of Biological Activities.
Lin R, et al.
Journal of Medicinal Chemistry, 48(13), 4208-4211 (2005)
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