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Merck
CN

525898

Methyl (1-methylindolyl)-3-glyoxylate

97%

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About This Item

Empirical Formula (Hill Notation):
C12H11NO3
CAS Number:
Molecular Weight:
217.22
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
97%
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InChI

1S/C12H11NO3/c1-13-7-9(11(14)12(15)16-2)8-5-3-4-6-10(8)13/h3-7H,1-2H3

SMILES string

COC(=O)C(=O)c1cn(C)c2ccccc12

InChI key

SBHIWUQNUXJUMN-UHFFFAOYSA-N

assay

97%

mp

96-100 °C (lit.)

Quality Level

General description

Methyl (1-methylindolyl)-3-glyoxylate can be prepared from 1-methylindole.

Application

  • Reactant for synthesis of sotrastaurin analogs
  • Reactant for preparation of protein kinase C (PKC) inhibitors
  • Reactant for preparation of indolyl diols
Methyl (1-methylindolyl)-3-glyoxylate may be used to synthesize 3-[(1-methyl)-3-indolyl]-4-(3-indolyl)-1H-pyrrole-2,5-dione and 3,4-[(1-methyl)-3-indolyl]-1H-pyrrole-2,5-dione.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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A New, Efficient Method for the Synthesis of Bisindolylmaleimides.
Margaret M. Faul et al.
The Journal of organic chemistry, 63(17), 6053-6058 (2001-10-24)

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