549835
2,4,6-Tris(dimethylamino)-1,3,5-triazine
96%
Synonym(s):
Altretamine, Hexamethylmelamine
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About This Item
Empirical Formula (Hill Notation):
C9H18N6
CAS Number:
Molecular Weight:
210.28
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
211-428-4
MDL number:
Assay:
96%
InChI key
UUVWYPNAQBNQJQ-UHFFFAOYSA-N
InChI
1S/C9H18N6/c1-13(2)7-10-8(14(3)4)12-9(11-7)15(5)6/h1-6H3
SMILES string
CN(C)c1nc(nc(n1)N(C)C)N(C)C
assay
96%
mp
171-175 °C (lit.)
functional group
amine
Quality Level
General description
2,4,6-Tris(dimethylamino)-1,3,5-triazine exhibits antitumor activity.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Triazines and related products. Part 26. Synthesis and chemistry of bicyclic analogues of the antitumour drug 2, 4, 6-tris (dimethylamino)-1, 3, 5-triazine (hexamethylmelamine).
Langdon SP, et al.
Journal of the Chemical Society. Perkin Transactions 1, 993-998 (1984)
Maurie Markman et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 24(9), 1454-1458 (2006-03-22)
A previous report suggested the nadir serum CA-125 level within the group of patients with ovarian cancer who achieved normalization of CA-125 accurately defined the risk of relapse. Using similar CA-125 subgroups, we sought to determine if the baseline CA-125
Medication sheets for patients. Oral chemotherapy.
Clinical journal of oncology nursing, 7(6 Suppl), 40-72 (2004-01-07)
P Sørensen et al.
Gynecologic oncology, 81(1), 58-62 (2001-03-30)
The purpose of this phase II study was to evaluate on an intent-to-treat basis the activity and toxicity of single-agent vinorelbine (VRL) as second-line chemotherapy of patients with platinum-resistant ovarian cancer. Platinum-resistant disease was defined as disease refractory to or
John K Chan et al.
Gynecologic oncology, 92(1), 368-371 (2004-01-31)
Altretamine has reported efficacy in the treatment of recurrent ovarian cancer following platinum-based therapy. This report presents the cases of two long-term survivors with recurrent ovarian cancer given oral altretamine. Two patients diagnosed with stage IIIC ovarian cancer underwent optimal
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