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Merck
CN

549975

3-(Diethylamino)propylamine

Synonym(s):

N,N-Diethyl-1,3-diaminopropane, N,N-Diethyl-1,3-propanediamine, DEAPA

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About This Item

Linear Formula:
(C2H5)2N(CH2)3NH2
CAS Number:
104-78-9
Molecular Weight:
130.23
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24874737
EC Number:
203-236-4
Beilstein/REAXYS Number:
741879
MDL number:
MFCD00008218
Assay:
99% (GC)

Key Documents

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InChI key

QOHMWDJIBGVPIF-UHFFFAOYSA-N

InChI

1S/C7H18N2/c1-3-9(4-2)7-5-6-8/h3-8H2,1-2H3

SMILES string

CCN(CC)CCCN

vapor density

4.4 (vs air)

vapor pressure

19.5 mmHg ( 70 °C)

assay

99% (GC)

autoignition temp.

419 °F

expl. lim.

11.6 %

refractive index

n20/D 1.4416 (lit.)

bp

159 °C (lit.)

density

0.826 g/mL at 25 °C (lit.)

functional group

amine

Quality Level

200

Related Categories

General description

3-(Diethylamino)propylamine (3-(diethylamino)-1-propylamine, DEAPA) is a diamine.

Application

3-(Diethylamino)propylamine may be used in the preparation of:
  • Biocompatible polyampholyte-coated (poly(acrylic acid)-co-3-(diethylamino)-propylamine magnetite nanoparticles (PAMNPs).
  • Hyaluronic acid grafted with 3-diethylaminopropyl (DEAP) group (HA-g-DEAP) nanoparticles for use as a drug delivery vehicle.
  • DEAPA-modified poly(vinyl alcohol) (PVA) polymers that can be employed in gene silencing.
It may also be used to introduce cationic groups during the surface modification of microfibrillated cellulose (MFC).

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1A - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

125.6 °F - closed cup

flash_point_c

52 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ6339
MKCR2621
MKCQ1088
MKCN8431
MKCK4279

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Juliane Nguyen et al.
Pharmaceutical research, 27(12), 2670-2682 (2010-09-18)
The objective of this study was to investigate how the degree of amine substitution of amine-modified poly(vinyl alcohol) (PVA) affects complexation of siRNA, protection of siRNA against degrading enzymes, intracellular uptake and gene silencing. A series of DEAPA-PVA polymers with
Low toxicity and long circulation time of polyampholyte-coated magnetic nanoparticles for blood pool contrast agents.
Wang Qi, et al.
Scientific Reports, 5, 7774-7774 (2015)
Chemical surface modifications of microfibrillated cellulose.
Stenstad P, et al.
Cellulose, 15(1), 35-45 (2008)
Hyaluronated nanoparticles with pH-and enzyme-responsive drug release properties.
Kim SW, et al.
Colloids and Surfaces. B, Biointerfaces, 116, 359-364 (2014)

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