556017
N-Boc-4-piperidinemethanol
97%
Synonym(s):
N-tert-Butyloxycarbonyl-4-piperidinemethanol
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About This Item
Empirical Formula (Hill Notation):
C11H21NO3
CAS Number:
Molecular Weight:
215.29
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
97%
Form:
solid
InChI
1S/C11H21NO3/c1-11(2,3)15-10(14)12-6-4-9(8-13)5-7-12/h9,13H,4-8H2,1-3H3
SMILES string
CC(C)(C)OC(=O)N1CCC(CO)CC1
InChI key
CTEDVGRUGMPBHE-UHFFFAOYSA-N
assay
97%
form
solid
mp
78-82 °C (lit.)
functional group
hydroxyl
General description
N-Boc-4-piperidinemethanol contains a tert-butyloxycarbonyl (t-BOC)-protecting group. It can be synthesized from 4-piperidinemethanol via reaction with di-tert-butyldicarbonate.
Application
N-Boc-4-piperidinemethanol may be used to synthesize:
- methyl 5-methoxy-4-(1-methylpiperidin-4-ylmethoxy)-2-nitrobenzoate
- N-Boc-4-piperidinecarboxaldehyde
- [1-(tert-butoxycarbonyl)piperidin-4-yl]methyl methanesulfonate
Involved in the synthesis of bradycardic agents.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Synthesis and nanostructures of 5, 10, 15, 20-tetrakis (4-piperidyl) porphyrin.
JacobsenJL, et al.
Tetrahedron, 69(48), 10507-10515 (2013)
Hideki Kubota et al.
Bioorganic & medicinal chemistry letters, 14(12), 3049-3052 (2004-05-20)
A series of piperidinoalkanoyl-1,2,3,4-tetrahydroisoquinoline derivatives were synthesized, and their bradycardic activities were investigated in the isolated right atria of guinea pigs and in conscious rats. These efforts identified the achiral compound 2f, which exhibited potent and long-lasting bradycardic activity with
Fluorine-18 labeling of 6, 7-disubstituted anilinoquinazoline derivatives for positron emission tomography (PET) imaging of tyrosine kinase receptors: synthesis of 18F-Iressa and related molecular probes.
Seimbille Y, et al.
Journal of Labelled Compounds & Radiopharmaceuticals, 48(11), 829-843 (2005)
Daniele Zampieri et al.
European journal of medicinal chemistry, 44(1), 124-130 (2008-04-29)
We describe here the synthesis and the binding interaction with sigma(1) and sigma(2) receptors of a series of new benzo[d]oxazol-2(3H)-one derivatives variously substituted on the N-benzyl moiety. The results of binding studies confirm the notion that the benzoxazolone moiety confers
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