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Merck
CN

58790

(+)-Potassium Ds-threo-isocitrate monobasic

≥98.0% (NT)

Synonym(s):

(1R,2S)-1-Hydroxy-1,2,3-propanetricarboxylic acid monopotassium salt, Ds-(+)-threo-Isocitric acid monopotassium salt

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About This Item

Empirical Formula (Hill Notation):
C6H7KO7
CAS Number:
20226-99-7
Molecular Weight:
230.21
MDL number:
MFCD00069566
UNSPSC Code:
51113400
PubChem Substance ID:
57651660
NACRES:
NA.22
Beilstein/REAXYS Number:
3767339

Key Documents

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Product Name

(+)-Potassium Ds-threo-isocitrate monobasic, ≥98.0% (NT)

SMILES string

[K+].O[C@H]([C@H](CC(O)=O)C([O-])=O)C(O)=O

InChI key

IVLPTBJBFVJENN-LEJBHHMKSA-M

InChI

1S/C6H8O7.K/c7-3(8)1-2(5(10)11)4(9)6(12)13;/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13);/q;+1/p-1/t2-,4+;/m0./s1

assay

≥98.0% (NT)

optical activity

[α]20/D +20.5±1°, c = 2% in H2O

mp

~185 °C (dec.)

functional group

carboxylic acid
hydroxyl

Quality Level

100

Related Categories

Application

(+)-Potassium Ds-threo-isocitrate monobasic may be used in the assessment of isocitrate dehydrogenase 2 (Idh2) activity by Kornberg method.

Other Notes

Substrate for the characterization of isocitrate dehydrogenase

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
363092/1

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Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis.
Liu TF, et al.
The Journal of Biological Chemistry, 290(1), 396-408 (2015)
Sarah E Anderson et al.
The Analyst, 145(11), 3899-3908 (2020-04-17)
The enzyme isocitrate dehydrogenase 1 (IDH1) catalyzes the conversion of isocitrate to alpha-ketoglutarate (αKG) and has emerged as an important therapeutic target for glioblastoma multiforme (GBM). Current methods for assaying IDH1 remain poorly suited for high-throughput screening of IDH1 antagonists.
H Eguchi et al.
Biochimica et biophysica acta, 990(2), 133-137 (1989-02-24)
NADP-dependent isocitrate dehydrogenase (EC 1.1.1.42) was purified to electrophoretic homogeneity from an extremely thermophilic bacterium, Thermus thermophilus HB8, and shown to be a dimeric protein of molecular weight 115,000, with a pI of 5.5. The amino acid composition of the
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Ashley S Williams et al.
Cell metabolism, 31(1), 131-147 (2019-12-10)
This study sought to examine the functional significance of mitochondrial protein acetylation using a double knockout (DKO) mouse model harboring muscle-specific deficits in acetyl-CoA buffering and lysine deacetylation, due to genetic ablation of carnitine acetyltransferase and Sirtuin 3, respectively. DKO

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