58790
(+)-Potassium Ds-threo-isocitrate monobasic
≥98.0% (NT)
Synonym(s):
(1R,2S)-1-Hydroxy-1,2,3-propanetricarboxylic acid monopotassium salt, Ds-(+)-threo-Isocitric acid monopotassium salt
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About This Item
Empirical Formula (Hill Notation):
C6H7KO7
CAS Number:
Molecular Weight:
230.21
MDL number:
UNSPSC Code:
51113400
PubChem Substance ID:
NACRES:
NA.22
Beilstein/REAXYS Number:
3767339
Assay:
≥98.0% (NT)
Quality Level
assay
≥98.0% (NT)
optical activity
[α]20/D +20.5±1°, c = 2% in H2O
mp
~185 °C (dec.)
functional group
carboxylic acid, hydroxyl
SMILES string
[K+].O[C@H]([C@H](CC(O)=O)C([O-])=O)C(O)=O
InChI
1S/C6H8O7.K/c7-3(8)1-2(5(10)11)4(9)6(12)13;/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13);/q;+1/p-1/t2-,4+;/m0./s1
InChI key
IVLPTBJBFVJENN-LEJBHHMKSA-M
Application
(+)-Potassium Ds-threo-isocitrate monobasic may be used in the assessment of isocitrate dehydrogenase 2 (Idh2) activity by Kornberg method.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Other Notes
Substrate for the characterization of isocitrate dehydrogenase
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis.
Liu TF, et al.
The Journal of Biological Chemistry, 290(1), 396-408 (2015)
H Eguchi et al.
Biochimica et biophysica acta, 990(2), 133-137 (1989-02-24)
NADP-dependent isocitrate dehydrogenase (EC 1.1.1.42) was purified to electrophoretic homogeneity from an extremely thermophilic bacterium, Thermus thermophilus HB8, and shown to be a dimeric protein of molecular weight 115,000, with a pI of 5.5. The amino acid composition of the
Sarah E Anderson et al.
The Analyst, 145(11), 3899-3908 (2020-04-17)
The enzyme isocitrate dehydrogenase 1 (IDH1) catalyzes the conversion of isocitrate to alpha-ketoglutarate (αKG) and has emerged as an important therapeutic target for glioblastoma multiforme (GBM). Current methods for assaying IDH1 remain poorly suited for high-throughput screening of IDH1 antagonists.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 58790-250MG | 04061832896342 |
| 58790-1G | 04061826065013 |