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Merck
CN

607851

L-Glutamic acid-13C5,15N

98 atom % 15N, 98 atom % 13C, 95% (CP)

Synonym(s):

(S)-2-Aminopentanedioic acid-13C5,15N, 13C and 15N Labeled L-glutamic acid, Glu-13C5,15N

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About This Item

Linear Formula:
HO213C(13CH2)213CH(15NH2)13CO2H
CAS Number:
202468-31-3
Molecular Weight:
153.09
MDL number:
MFCD00144596
UNSPSC Code:
12352209
PubChem Substance ID:
24881981
NACRES:
NA.12

Key Documents

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isotopic purity

98 atom % 13C
98 atom % 15N

Quality Level

200

Assay

95% (CP)

form

solid

optical activity

[α]25/D +31.0°, c = 2 in 5 M HCl

technique(s)

bio NMR: suitable

mp

205 °C (dec.) (lit.)

mass shift

M+6

SMILES string

[15NH2][13C@@H]([13CH2][13CH2][13C](O)=O)[13C](O)=O

InChI

1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1/i1+1,2+1,3+1,4+1,5+1,6+1

InChI key

WHUUTDBJXJRKMK-UFLWJPECSA-N

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General description

Glutamic acid is an amino acid with an acidic side group. It works as a proton donor. Decarboxylation of glutamic acid results in the formation of GABA (γ aminobutyric acid), a potent neurotransmitter. Isotope labeled amino acids are required for the production of isotopically labeled proteins.

Packaging

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MBBF0562
MBBF0279
MBBD7120
MBBC6615
MBBC6417

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Kishore K Mahalingan et al.
Nature structural & molecular biology, 27(9), 802-813 (2020-08-05)
Glutamylation, introduced by tubulin tyrosine ligase-like (TTLL) enzymes, is the most abundant modification of brain tubulin. Essential effector proteins read the tubulin glutamylation pattern, and its misregulation causes neurodegeneration. TTLL glutamylases post-translationally add glutamates to internal glutamates in tubulin carboxy-terminal
Fumihiro Eto et al.
Scientific reports, 10(1), 7435-7435 (2020-05-06)
The brain consists of various areas with anatomical features. Neurons communicate with one another via excitatory or inhibitory synaptic transmission. Altered abundance of neurotransmitters, including glutamate and gamma-aminobutyric acid (GABA), in specific brain regions is closely involved in severe neurological
Incorporation of radioactive amino acids into proteins of the microsome fraction of guinea-pig liver in a cell-free system.
SIMKIN JL and WORK TS
The Biochemical Journal, 67, 617-624 (1957)
The incorporation of radioactive amino acids into proteins of the microsome fraction of guinea-pig liver at very short time intervals after administration.
Simkin JL and Sutton CR
The Biochemical Journal, 77, 489-492 (1960)
Garrett RH and Grisham CM
Biochemistry (2012)
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