608106
L-Methionine-13C5,15N
98 atom % 13C, 98 atom % 15N, 95% (CP)
Synonym(s):
SILAC Amino Acid, L-Methionine-ul-13C,15N
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About This Item
Linear Formula:
13CH3S13CH213CH213CH(15NH2)13CO2H
CAS Number:
Molecular Weight:
155.17
NACRES:
NA.12
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Isotopic purity:
98 atom % 13C, 98 atom % 15N
Assay:
95% (CP)
Mass shift:
M+6
Form:
solid
InChI
1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1/i1+1,2+1,3+1,4+1,5+1,6+1
SMILES string
[13CH3]S[13CH2][13CH2][13C@H]([15NH2])[13C](O)=O
InChI key
FFEARJCKVFRZRR-XAFSXMPTSA-N
isotopic purity
98 atom % 13C, 98 atom % 15N
assay
95% (CP)
form
solid
optical activity
[α]25/D +23.1°, c = 1 in 1 M HCl
technique(s)
bio NMR: suitable, protein expression: suitable
mp
284 °C (dec.) (lit.)
mass shift
M+6
Quality Level
Related Categories
Application
L-Methionine-13C5,15N can be used as an internal standard in the analysis of amino acids in human plasma and serum using various analytical techniques.
Packaging
This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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High-speed quantitative UPLC-MS analysis of multiple amines in human plasma and serum via precolumn derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate: application to acetaminophen-induced liver failure
Gray N, et al.
Analytical Chemistry, 89(4), 2478-2487 (2017)
Comparison of orthogonal liquid and gas chromatography--mass spectrometry platforms for the determination of amino acid concentrations in human plasma
McGaw EA, et al.
Journal of Chromatography A, 1217(37), 5822-5831 (2010)
The interactome of the N-terminus of band 3 regulates red blood cell metabolism and storage quality.
Aaron Issaian et al.
Haematologica (2021-05-14)
Band 3 (anion exchanger 1 - AE1) is the most abundant membrane protein in red blood cells (RBCs), the most abundant cell in the human body. A compelling model posits that - at high oxygen saturation - the N-term cytosolic
Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming.
Dominic G Roy et al.
Cell metabolism, 31(2), 250-266 (2020-02-06)
Epigenetic modifications on DNA and histones regulate gene expression by modulating chromatin accessibility to transcription machinery. Here we identify methionine as a key nutrient affecting epigenetic reprogramming in CD4+ T helper (Th) cells. Using metabolomics, we showed that methionine is
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