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Merck
CN

641472

1-Boc-4-(aminomethyl)piperidine

97%

Synonym(s):

1,1-Dimethylethyl 4-(aminomethyl)-1-piperidinecarboxylate, N-(tert-Butoxycarbonyl)-4-aminomethylpiperidine

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About This Item

Empirical Formula (Hill Notation):
C11H22N2O2
CAS Number:
Molecular Weight:
214.30
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
97%
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Product Name

1-Boc-4-(aminomethyl)piperidine, 97%

InChI

1S/C11H22N2O2/c1-11(2,3)15-10(14)13-6-4-9(8-12)5-7-13/h9H,4-8,12H2,1-3H3

SMILES string

CC(C)(C)OC(=O)N1CCC(CN)CC1

InChI key

KLKBCNDBOVRQIJ-UHFFFAOYSA-N

assay

97%

refractive index

n20/D 1.473 (lit.)

bp

237-238 °C (lit.)

density

1.013 g/mL at 25 °C (lit.)

functional group

amine

Quality Level

Application

Precursor in the preparation of a variety of different protein agonists or antagonists including:
  • Kinesin spindle protein inhibitors with potential anticancer activity
  • Orphan G-protein coupled receptor GPR119 agonist with antidiabetic potential
  • Pim-1 inhibitors
  • Aspartic acid protease inhibitors

Reactant involved in enantioselective synthesis of N-alkyl terminal aziridines

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

No data available

flash_point_c

No data available

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

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Articles

Mono-Boc-protected diamines are versatile building blocks for chemical synthesis. Their production is a lot more challenging than the simple reaction scheme might imply, because the Boc-anhydride reagent cannot differentiate between the two identical amino moieties in the substrate.

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