651699
1-(1-Naphthylmethyl)piperazine
95%
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About This Item
Empirical Formula (Hill Notation):
C15H18N2
CAS Number:
Molecular Weight:
226.32
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Product Name
1-(1-Naphthylmethyl)piperazine, 95%
InChI
1S/C15H18N2/c1-2-7-15-13(4-1)5-3-6-14(15)12-17-10-8-16-9-11-17/h1-7,16H,8-12H2
SMILES string
C1CN(CCN1)Cc2cccc3ccccc23
InChI key
HGYDREHWXXUUIS-UHFFFAOYSA-N
assay
95%
form
solid
mp
63-67 °C (lit.)
signalword
Warning
hcodes
Hazard Classifications
Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Ram Prosad Chakrabarty et al.
AMB Express, 6(1), 126-126 (2016-12-23)
The study aims at revealing the comprehensive contribution of target alteration, target protection and efflux pump to the development of high level of ciprofloxacin (CIP) resistance in Enterobacteriaceae bacteria of environmental, clinical and poultry origins. Antibiotic susceptibility test was used
Contribution of AcrAB-TolC to multidrug resistance in an Escherichia coli sequence type 131 isolate.
Sabine Schuster et al.
International journal of antimicrobial agents, 50(3), 477-481 (2017-07-12)
Drug efflux by resistance-nodulation-cell division (RND)-type transporters, such as AcrAB-TolC of Escherichia coli, is an important resistance mechanism in Gram-negative bacteria; however, its contribution to multidrug resistance (MDR) in clinical isolates is poorly defined. We inactivated acrB of a sequence
João Anes et al.
Frontiers in microbiology, 10, 92-92 (2019-03-01)
Antimicrobial efflux is one of the important mechanisms causing multi-drug resistance (MDR) in bacteria. Chemosensitizers like 1-(1-naphthylmethyl)-piperazine (NMP) can inhibit an efflux pump and therefore can overcome MDR. However, secondary effects of NMP other than efflux pump inhibition are rarely
Zachary P Howard et al.
Infection and immunity, 88(12) (2020-09-16)
Coxiella burnetii is a zoonotic bacterial obligate intracellular parasite and the cause of query (Q) fever. During natural infection of female animals, C. burnetii shows tropism for the placenta and is associated with late-term abortion, at which time the pathogen
Jun-Ren Sun et al.
PloS one, 7(11), e49534-e49534 (2012-11-21)
Over-expression of AdeABC efflux pump stimulated continuously by the mutated AdeRS two component system has been found to result in antimicrobial resistance, even tigecycline (TGC) resistance, in multidrug-resistant Acinetobacter baumannii (MRAB). Although the insertion sequence, ISAba1, contributes to one of
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