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651753

2-Chloro-5-fluoropyrimidine

97%

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About This Item

Empirical Formula (Hill Notation):
C4H2ClFN2
CAS Number:
62802-42-0
Molecular Weight:
132.52
NACRES:
NA.22
PubChem Substance ID:
24883860
UNSPSC Code:
12352100
MDL number:
MFCD03788197
Assay:
97%
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assay

97%

refractive index

n20/D 1.503 (lit.)

density

1.439 g/mL at 20 °C (lit.)

functional group

chloro, fluoro

SMILES string

Fc1cnc(Cl)nc1

InChI

1S/C4H2ClFN2/c5-4-7-1-3(6)2-8-4/h1-2H

InChI key

AGYUQBNABXVWMS-UHFFFAOYSA-N

Application

2-Chloro-5-fluoropyrimidine can be used as a starting material for the preparation of:
  • 5-fluoro-2-amino pyrimidines by reacting with various amines in the presence of K2CO3, via C-N bond forming reaction.
  • 2-chloro-5-(5-fluoropyrimidin-2-yl)benzoic acid, an intermediate, which is used in the synthesis of benzamide scaffolds as potent antagonists against P2X7 receptors.
  • 5-fluoro-2-cyano pyrimidine, a key intermediate used for the synthesis of 5-chloro-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine, as a potent inhibitor of the JAK2 kinase.

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

hcodes

H302,H314

Hazard Classifications

Acute Tox. 4 Oral - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 3

flash_point_f

149.0 °F - closed cup

flash_point_c

65 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKBK3201V
MKBG1563V
MKAA0810
03806KH
05510EH

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Metal-free site-selective C-N bond-forming reaction of polyhalogenated pyridines and pyrimidines
Wang L, et al.
Royal Society of Chemistry Advances, 5(100), 82097-82111 (2015)
Discovery of 2-chloro-N-((4, 4-difluoro-1-hydroxycyclohexyl) methyl)-5-(5-fluoropyrimidin-2-yl) benzamide as a potent and CNS penetrable P2X7 receptor antagonist
Chen X, et al.
Bioorganic & Medicinal Chemistry Letters, 20(10), 3107-3111 (2010)
Use of ?-transaminase enzyme chemistry in the synthesis of a JAK2 kinase inhibitor
Frodsham L, et al.
Organic Process Research & Development, 17(9), 1123-1130 (2013)

Global Trade Item Number

SKUGTIN
651753-250MG04061832250441
651753-1G04061825745541