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653233

2,4-Dichloro-5-fluoropyrimidine

97%

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About This Item

Empirical Formula (Hill Notation):
C4HCl2FN2
CAS Number:
2927-71-1
Molecular Weight:
166.97
NACRES:
NA.22
PubChem Substance ID:
24883938
UNSPSC Code:
12352100
MDL number:
MFCD00233551
Assay:
97%
Form:
solid
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Quality Segment

100

assay

97%

form

solid

mp

37-41 °C (lit.)

functional group

chloro, fluoro

SMILES string

Fc1cnc(Cl)nc1Cl

InChI

1S/C4HCl2FN2/c5-3-2(7)1-8-4(6)9-3/h1H

InChI key

WHPFEQUEHBULBW-UHFFFAOYSA-N

Application

2,4-Dichloro-5-fluoropyrimidine can be used as a starting material to synthesize:
  • 5-fluoropyrimidine-2-carboxamides and 5-fluoropyrimidine-4-carboxamides as potential kinase inhibitors.
  • A series of 2,4-diamino-5-fluoropyrimidine derivatives as potential protein kinase Cθ inhibitors.
  • 2,4-Bisanilinopyrimidine derivatives as potential aurora kinases inhibitors.
  • 5-fluoro-N,N-bis(4-methoxyphenyl)-2,4-pyrimidinediamine by reacting with p-methoxy aniline in the presence of DIPEA.
  • 2-chloro-5-fluoro-4-(4-fluorophenyl)pyrimidine by Suzuki coupling reaction in the presence of (4-fluorophenyl)boronic acid triphenylphosphine, and palladium(II) acetate catalyst.
  • 5-fluoro-2-(piperidin-4-yloxy)pyrimidin-4-amine, a scaffold, which is used in the preparation of potent deoxycytidine kinase inhibitors.

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1A

Storage Class

8A - Combustible corrosive hazardous materials

flash_point_f

222.8 °F - closed cup

flash_point_c

106 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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