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653683

5-Nitro-2-oxindole

97%

Synonym(s):

5-Nitro-1,3-dihydroindole-2-one, NSC 25199, NSC 99066

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About This Item

Empirical Formula (Hill Notation):
C8H6N2O3
CAS Number:
20870-79-5
Molecular Weight:
178.14
NACRES:
NA.22
PubChem Substance ID:
24883978
UNSPSC Code:
12352100
MDL number:
MFCD00456999
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assay

97%

form

solid

mp

233-236 °C

SMILES string

[O-][N+](=O)c1ccc2NC(=O)Cc2c1

InChI

1S/C8H6N2O3/c11-8-4-5-3-6(10(12)13)1-2-7(5)9-8/h1-3H,4H2,(H,9,11)

InChI key

JQCGHRDKVZPCRO-UHFFFAOYSA-N

Application

  • Reactant for synthesis of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors
  • Reactant for preparation of Aurora kinase inhibitors
  • Reactant for synthesis of 3-substituted 2-indolinone RET inhibitors
  • Reactant for synthesis of 4-azachromeno[2,3-b]indol-11(6H)-ones and derivatives as analogs of ellipticine
  • Reactant for preparation of [18F]fluorobenzylidene-indolinone as possible tyrosine kinase inhibitor for PET tumor imaging
  • Reactant for preparation of 3-substituted indolin-2-ones as neuroprotective and toxic agents

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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