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656402

2-Fluoroadenosine

Name: 2-Fluoroadenosine
Brand: ALDRICH

97%

Synonym(s):

2-Fluoro-9-β-D-ribofuranosyladenine

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₂FN₅O₄

CAS Number:

146-78-1

Molecular Weight:

285.23

NACRES:

NA.22

PubChem Substance ID:

24884201

UNSPSC Code:

41106305

MDL number:

MFCD00866394

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Properties

Quality Level

100

assay

97%

form

solid

mp

240 °C (D) (lit.)

SMILES string

Nc1nc(F)nc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O

InChI

1S/C10H12FN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6-,9-/m1/s1

InChI key

HBUBKKRHXORPQB-UUOKFMHZSA-N

Gene Information

human ... ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)

Description

pictograms

GHS07

signalword

Warning

hcodes

H302,H315,H319,H335

pcodes

P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

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Synergistic inhibition of platelet aggregation by forskolin plus PGE1 or 2-fluoroadenosine: effects of 2',5'-dideoxyadenosine and 5'-methylthioadenosine.

K C Agarwal et al.

Biochemical pharmacology, 31(22), 3713-3716 (1982-11-15)

Expression of methylthioadenosine phosphorylase cDNA in p16-, MTAP- malignant cells: restoration of methylthioadenosine phosphorylase-dependent salvage pathways and alterations of sensitivity to inhibitors of purine de novo synthesis.

Z H Chen et al.

Molecular pharmacology, 52(5), 903-911 (1997-11-14)

5'-Deoxy-5'-methylthioadenosine phosphorylase (MTAP) is involved in the salvage of adenine and methylthio moieties of 5'-deoxy-5'-methylthioadenosine, a byproduct of polyamine synthesis, to adenine nucleotides and methionine, respectively. The gene encoding MTAP, MTAP, is frequently codeleted along with the tumor suppressor gene

Biodistribution and PET imaging of [(18)F]-fluoroadenosine derivatives.

Mian M Alauddin et al.

Nuclear medicine and biology, 34(3), 267-272 (2007-03-27)

Many fluorinated analogues of adenosine nucleoside have been synthesized and studied as potential antitumor and antiviral agents. Earlier, we reported radiosynthesis of 2'-deoxy-2'-[(18)F]fluoro-1-beta-D-arabinofuranosyl-adenine ([(18)F]-FAA) and 3'-deoxy-3'-[(18)F]fluoro-1-beta-d-xylofuranosyl-adenine ([(18)F]FXA). Now, we report their in vivo studies including blood clearance, biodistribution and micro-PET

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Global Trade Item Number

SKU	GTIN
656402-250MG	04061833483534
656402-1G	04061826699218