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Merck
CN

656445

5-Fluoro-2-hydroxypyrimidine

97%

Synonym(s):

5-Fluoro-2(1H)-pyrimidone

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About This Item

Empirical Formula (Hill Notation):
C4H3FN2O
CAS Number:
2022-78-8
Molecular Weight:
114.08
NACRES:
NA.22
PubChem Substance ID:
24884205
UNSPSC Code:
12352100
MDL number:
MFCD00223678
Assay:
97%
Form:
solid

Key Documents

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InChI

1S/C4H3FN2O/c5-3-1-6-4(8)7-2-3/h1-2H,(H,6,7,8)

SMILES string

Oc1ncc(F)cn1

InChI key

HPABFFGQPLJKBP-UHFFFAOYSA-N

assay

97%

form

solid

mp

170-174 °C

functional group

fluoro

Application

5-Fluoro-2-hydroxypyrimidine can be used as a reactant in the preparation of:
  • Manganese fluoro(hydroxy)pyrimidinato aqua dinuclear complex [Mn2(Fpymo)4(H2O)4].
  • 2-Chloro-5-fluoropyrimidine by treating with POCl3.

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCK9266
MKCG7347
MKBP0639V
MKBG8824V
03006BJ

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Patricia M LoRusso et al.
Investigational new drugs, 20(1), 63-71 (2002-05-11)
5-Fluoro-Pyrimidinone (5FP) is an oral pro-drug of 5-Fluorouracil (5FU), and is converted to 5FU by hepatic aldehyde oxidase. Preclinically, 5FP demonstrated anti-tumor activity against colon 38 and P 388 leukemia models in mice. Using an accelerated titration trial design with
[Mn2 (Fpymo) 4 (H2O) 4]: Synthesis, structure, magnetism and thermally induced solid-to-solid polymerisation reactions
Ruiz-Agudo E, et al.
Inorgorganica Chimica Acta, 360(1), 84-90 (2007)
Chemoselectivity and regioselectivity in reactions of pyrimidines
GACEK M and UNDHEIM K
Acta Chemica Scandinavica, Series A: Physical and Inorganic Chemistry, 39, 691-696 (1985)

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