656445
5-Fluoro-2-hydroxypyrimidine
97%
Synonym(s):
5-Fluoro-2(1H)-pyrimidone
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About This Item
Empirical Formula (Hill Notation):
C4H3FN2O
CAS Number:
Molecular Weight:
114.08
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Product Name
5-Fluoro-2-hydroxypyrimidine, 97%
InChI
1S/C4H3FN2O/c5-3-1-6-4(8)7-2-3/h1-2H,(H,6,7,8)
SMILES string
Oc1ncc(F)cn1
InChI key
HPABFFGQPLJKBP-UHFFFAOYSA-N
assay
97%
form
solid
mp
170-174 °C
functional group
fluoro
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Application
5-Fluoro-2-hydroxypyrimidine can be used as a reactant in the preparation of:
- Manganese fluoro(hydroxy)pyrimidinato aqua dinuclear complex [Mn2(Fpymo)4(H2O)4].
- 2-Chloro-5-fluoropyrimidine by treating with POCl3.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Chemoselectivity and regioselectivity in reactions of pyrimidines
GACEK M and UNDHEIM K
Acta Chemica Scandinavica, Series A: Physical and Inorganic Chemistry, 39, 691-696 (1985)
[Mn2 (Fpymo) 4 (H2O) 4]: Synthesis, structure, magnetism and thermally induced solid-to-solid polymerisation reactions
Ruiz-Agudo E, et al.
Inorgorganica Chimica Acta, 360(1), 84-90 (2007)
Patricia M LoRusso et al.
Investigational new drugs, 20(1), 63-71 (2002-05-11)
5-Fluoro-Pyrimidinone (5FP) is an oral pro-drug of 5-Fluorouracil (5FU), and is converted to 5FU by hepatic aldehyde oxidase. Preclinically, 5FP demonstrated anti-tumor activity against colon 38 and P 388 leukemia models in mice. Using an accelerated titration trial design with
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