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65671

(R)-1-{(RP)-2-[2-(Diphenylphosphino)phenyl]ferrocenyl}ethylbis[3,5-bis-(trifluoromethyl)phenyl]phosphine

≥97%

Synonym(s):

(1S)-1-[(1R)-1-[Bis[3,5-bis(trifluoromethyl)phenyl]phosphino]ethyl]-2-[2-(diphenylphosphino)phenyl]ferrocene, Walphos SL-W001-2

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About This Item

Empirical Formula (Hill Notation):
C46H32F12FeP2
CAS Number:
387868-06-6
Molecular Weight:
930.52
NACRES:
NA.22
PubChem Substance ID:
24884219
UNSPSC Code:
12352101
MDL number:
MFCD08561122
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Quality Level

100

assay

≥97%

optical purity

ee: ≥99%

functional group

fluoro, phosphine

SMILES string

[Fe].[CH]1[CH][CH][CH][CH]1.C[C@@H]([C]2[CH][CH][CH][C]2c3ccccc3P(c4ccccc4)c5ccccc5)P(c6cc(cc(c6)C(F)(F)F)C(F)(F)F)c7cc(cc(c7)C(F)(F)F)C(F)(F)F

InChI

1S/C41H27F12P2.C5H5.Fe/c1-25(34-16-10-17-35(34)36-15-8-9-18-37(36)55(30-11-4-2-5-12-30)31-13-6-3-7-14-31)54(32-21-26(38(42,43)44)19-27(22-32)39(45,46)47)33-23-28(40(48,49)50)20-29(24-33)41(51,52)53;1-2-4-5-3-1;/h2-25H,1H3;1-5H;/t25-;;/m0../s1

InChI key

LKNKYBWIZNAXBY-WLOLSGMKSA-N

General description

The product is an air-stable and non-hygroscopic Solvias chiral phosphine ligand.

Application

Walphos SL-W001-2, in the presence of a ruthenium catalyst may be used as a ligand in the following processes:
  • Asymmetric hydrogenation of IPCA-D, a cinnamic acid derivative.
  • Addition of 3,5-difluorophenylketimine to 4-methoxyphenylboronic acid to form the corresponding tertiary substituted cyclic sulfamate derivative with high enantioselctivity.2

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

sold in collaboration with Solvias AG

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG2465
BCCL2019
BCCH4430
BCCF2956
BCCB9934

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Enantioselective Rh (I)-catalyzed addition of arylboronic acids to cyclic ketimines.
Kong J, et al.
Organic Letters, 17(22), 5520-5523 (2015)
Afrooz Zirakzadeh et al.
Organometallics, 33(8), 1945-1952 (2014-05-06)
Two representative Walphos analogues with an achiral 2,2″-biferrocenediyl backbone were synthesized. These diphosphine ligands were tested in the rhodium-catalyzed asymmetric hydrogenation of several alkenes and in the ruthenium-catalyzed hydrogenation of two ketones. The results were compared with those previously obtained

Global Trade Item Number

SKUGTIN
65671-50G04061832623566
65671-5G04061832623573
65671-100G04061832623528
65671-1G04061826083956
65671-100MG04061832623535
65671-250G04061832623542
65671-500MG04061832623559