658774
Salicylaldehyde thiosemicarbazone
95%
Synonym(s):
2-Hydroxybenzaldehyde thiosemicarbazone, 2-[(2-Hydroxyphenyl)methylene]hydrazinecarbothioamide, o-Hydroxybenzaldehyde thiosemicarbazone
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About This Item
Linear Formula:
HOC6H4CH=NNHC(S)NH2
CAS Number:
Molecular Weight:
195.24
UNSPSC Code:
12352100
PubChem Substance ID:
MDL number:
Assay:
95%
Form:
solid
form
solid
InChI
1S/C8H9N3OS/c9-8(13)11-10-5-6-3-1-2-4-7(6)12/h1-5,12H,(H3,9,11,13)/b10-5+
SMILES string
NC(=S)N\N=C/c1ccccc1O
InChI key
OHNSRYBTSVDDKA-BJMVGYQFSA-N
assay
95%
mp
>230 °C
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Pabla Noblía et al.
Journal of inorganic biochemistry, 99(2), 443-451 (2004-12-29)
As a contribution to the development of novel vanadium complexes with pharmacologically interesting moieties, new dioxovanadium(V) semicarbazone complexes with the formula cis-VO(2)L, where L=5-bromosalicylaldehyde semicarbazone and 2-hydroxynaphtalen-1-carboxaldehyde semicarbazone have been synthesized and characterized by (1)H and (13)C NMR, Raman and
R Prabhakaran et al.
Metallomics : integrated biometal science, 3(1), 42-48 (2010-12-07)
Bis salicylaldehyde-4(N)-ethylthiosemicarbazone ruthenium(iii) triphenylphosphine [Ru(Sal-etsc)(H-Sal-etsc)(PPh(3))] was synthesized and structurally characterized by spectral and X-ray crystallographic studies and it showed 100% inhibition on the DPPH radical. It also exhibited a significant lymphocyte activity and inhibitory effect on the lung carcinoma A549
D Chattopadhyay et al.
Acta crystallographica. Section C, Crystal structure communications, 44 ( Pt 6), 1025-1028 (1988-06-15)
C8H9N3OS, monoclinic, C2/c, a = 14.206 (3), b = 14.244 (4), c = 10.457 (4) A, beta = 116.18(2) degrees, V = 1898.9 (8) A3, Z = 8, Dm = 1.387, D chi = 1.366 g cm-3, lambda(Mo K alpha)
Eswaran Ramachandran et al.
Metallomics : integrated biometal science, 4(2), 218-227 (2011-11-22)
New complexes, [Ni(HL)(PPh(3))]Cl (1), [Pd(L)(PPh(3))](2), and [Pd(L)(AsPh(3))](3), were synthesized from the reactions of 4-chloro-5-methyl-salicylaldehyde thiosemicarbazone [H(2)L] with [NiCl(2)(PPh(3))(2)], [PdCl(2)(PPh(3))(2)] and [PdCl(2)(AsPh(3))(2)]. They were characterized by IR, electronic, (1)H-NMR spectral data. Further, the structures of the complexes have been determined by
Kevin J Duffy et al.
Journal of medicinal chemistry, 45(17), 3573-3575 (2002-08-09)
High-throughput screening has resulted in the discovery of thiosemicarbazone thrombopoietin mimics. A shared pharmacophore hypothesis between this series and a previously identified class, the pyrazol-4-ylidenehydrazines, led to the rapid optimization of both potency and efficacy of the thiosemicarbazones. The application
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