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660078

(R)-(−)-1-Cbz-3-aminopyrrolidine

Name: (<I>R</I>)-(−)-1-Cbz-3-aminopyrrolidine
Brand: ALDRICH

97%

Synonym(s):

(R)-1-Benzyloxycarbonyl-3-aminopyrrolidine

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₁₆N₂O₂

CAS Number:

122536-73-6

Molecular Weight:

220.27

NACRES:

NA.22

PubChem Substance ID:

24884456

UNSPSC Code:

12352005

MDL number:

MFCD05864624

Assay:

97%

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Properties

assay

97%

refractive index

n20/D 1.548

bp

315 °C

density

1.155 g/mL at 25 °C

functional group

phenyl

SMILES string

N[C@@H]1CCN(C1)C(=O)OCc2ccccc2

InChI

1S/C12H16N2O2/c13-11-6-7-14(8-11)12(15)16-9-10-4-2-1-3-5-10/h1-5,11H,6-9,13H2/t11-/m1/s1

InChI key

FPXJNSKAXZNWMQ-LLVKDONJSA-N

Description

Application

(R)-(−)-1-Cbz-3-aminopyrrolidine can be used:

In one of the key synthetic steps for the preparations of AZ82, a KIFC1-specific inhibitor for cancer therapy.
As a key intermediate in the synthesis of N⁶-substituted adenosine analogs as potent A₁AR agonists.

pictograms

GHS07

signalword

Warning

hcodes

H302,H315,H319,H335

pcodes

P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

>230.0 °F - closed cup

flash_point_c

> 110 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

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Discovery and mechanistic study of a small molecule inhibitor for motor protein KIFC1

Wu J, et al.

ACS Chemical Biology, 8(10), 2201-2208 (2013)

Structure-activity relationships of adenosines with heterocyclic N6-substituents

Ashton TD, et al.

Bioorganic & Medicinal Chemistry Letters, 17(24), 6779-6784 (2007)

Global Trade Item Number

SKU	GTIN
660078-1G	04061826130308