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Merck
CN

664049

PAMAM Dendrimer Kit, generations 4-7

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About This Item

UNSPSC Code:
12162002
NACRES:
NA.23
eCl@ss:
32161000

Key Documents

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description

amino surface groups

feature

core type ethylenediamine core (2-carbon core)

storage temp.

2-8°C

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Application

PAMAM Dendrimer Kit, generations 4-7 can be used to formulate poorly water-soluble drugs to increase water solubility, and therefore enhance the bioavailability of these drugs. It can also be applied to catalysts and organic molecules, where dendrimers function as solubility enhancers and modifiers, allowing to mix otherwise immiscible materials.

General description

Ethylenediamine-core poly(amidoamine) (PAMAM) dendrimers are highly branched, “tree-like” core-shell nanostructures made up of amide and amine functional subunits.

Legal Information

Manufactured by Dendritech®, Inc.
Dendritech is a registered trademark of Dendritech, Inc.

Packaging

unit weight includes solvent

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Storage Class

3 - Flammable liquids

flash_point_f

51.8 °F - closed cup

flash_point_c

11 °C - closed cup

Regulatory Information

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Poly (amidoamine) dendrimers as a pharmaceutical excipient. Are we there yet?
Otto DP and De Villiers MM
Journal of Pharmaceutical Sciences, 107(1), 75-83 (2018)
Esen Efeoglu et al.
The Analyst, 142(20), 3848-3856 (2017-09-13)
Although consumer exposure to nanomaterials is ever increasing, with potential increased applications in areas such as drug and/or gene delivery, contrast agents and diagnosis, the determination of the cyto- and geno-toxic effects of nanomaterials on human health and the environment
Heck reactions catalyzed by PAMAM-dendrimer encapsulated Pd (0) nanoparticles
Rahim EH, et al.
Nano Letters, 1(9), 499-501 (2001)
PAMAM dendrimer: a pH-controlled nanosponge
Maiti PK
Canadian Journal of Chemistry, 95(9), 991-998 (2017)

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The recent emergence of a number of highly functional nanomaterials has enabled new approaches to the understanding, diagnosis, and treatment of cancer.

Solubility Enhancement with Dendrimers

Replace volatile organic solvents with water due to environmental concerns, overcoming challenges in solubility.

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