67070
1-Methylguanine
≥95%
Synonym(s):
2-Amino-6-hydroxy-1-methylpurine
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About This Item
Empirical Formula (Hill Notation):
C6H7N5O
CAS Number:
Molecular Weight:
165.15
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
213-348-5
Beilstein/REAXYS Number:
149730
MDL number:
InChI key
RFLVMTUMFYRZCB-UHFFFAOYSA-N
InChI
1S/C6H7N5O/c1-11-5(12)3-4(9-2-8-3)10-6(11)7/h2H,1H3,(H2,7,10)(H,8,9)
SMILES string
CN1C(N)=Nc2[nH]cnc2C1=O
assay
≥95%
mp
≥300 °C
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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S J Kerr
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 6(2), 123-131 (1985-01-01)
Primary Chinese hamster embryo cultures exposed chronically to 1-methylguanine or 7-methylguanine, modified purines derived from nucleic acid turnover, exhibit a number of properties characteristic of transformed cell lines. One of the earliest effects observed following exposure of cells to the
S J Kerr
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 6(2), 115-121 (1985-01-01)
1-Methylguanine and 7-methylguanine are naturally occurring modified purines derived from tRNA, found in elevated levels in the serum and urine of cancer patients. When C3H/10T1/2 clone-8 mouse cells are exposed to low levels of the methylated purines, they are induced
Pål Ø Falnes
Nucleic acids research, 32(21), 6260-6267 (2004-12-04)
The Escherichia coli AlkB protein repairs 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) lesions in DNA and RNA by oxidative demethylation, a reaction requiring ferrous iron and 2-oxoglutarate as cofactor and co-substrate, respectively. Here, we have studied the activity of AlkB proteins
Increases in methylated nucleosides during human pregnancy.
R J Simmonds et al.
Advances in experimental medicine and biology, 165 Pt A, 291-295 (1984-01-01)
H Kaur et al.
The Biochemical journal, 318 ( Pt 1), 21-23 (1996-08-15)
Oxidative DNA damage is thought to be an important contributor to cancer development and to be affected by dietary constituents, so its accurate measurement is important. DNA methylation is recognized as an important mechanism affecting gene expression. In the present
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