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679097

(R)-(−)-2-Methylpyrrolidine

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About This Item

Empirical Formula (Hill Notation):
C5H11N
CAS Number:
41720-98-3
Molecular Weight:
85.15
NACRES:
NA.22
PubChem Substance ID:
24885467
UNSPSC Code:
12352005
MDL number:
MFCD07783026
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refractive index

n20/D 1.4353

Quality Level

100

density

0.842 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

C[C@@H]1CCCN1

InChI

1S/C5H11N/c1-5-3-2-4-6-5/h5-6H,2-4H2,1H3/t5-/m1/s1

InChI key

RGHPCLZJAFCTIK-RXMQYKEDSA-N

Application

(R)-(−)-2-Methylpyrrolidine, an optically active amine that can be used as a key building block to synthesize:
  • 4,5-fused pyridazinone derivatives are applicable as potent histamine H3 receptor antagonists.
  • Naphthalenoid histamine H3 receptor antagonist.
  • Pyrrolo[2,3-d]pyrimidine derivatives as potent inhibitors of leucine-rich repeat kinase 2.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Flam. Liq. 2 - Skin Corr. 1B

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

45.0 °F - closed cup

flash_point_c

7.22 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKCQ6990
MKCH1973
MKCF6626
MKCF2901
MKBW5596V

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In vitro SAR of pyrrolidine-containing histamine H 3 receptor antagonists: Trends across multiple chemical series
Nersesian, Diana L., et al.
Bioorganic & Medicinal Chemistry Letters, 18.1, 355-359 (2008)
Optical Activation of Racemic a-Substituted Carbonyl Compounds Using Optically Active Amines.
Matsushita H, et al.
Bulletin of the Chemical Society of Japan, 49(7), 1928-1930 (1976)
An expedient and multikilogram synthesis of a naphthalenoid H3 antagonist.
Pu YM, et al.
Organic Process Research & Development, 11(6), 1004-1009 (2007)
View All Related Papers

Global Trade Item Number

SKUGTIN
679097-1G04061837895074