Key Documents

View All Documentation

702757

Potassium tert-pentoxide solution

Name: Potassium <I>tert</I>-pentoxide solution
Brand: ALDRICH

2 M in THF

Synonym(s):

Potassium tert-amylate, Potassium (2-methyl-2-butoxide), Potassium tert-pentylate

Select a Size

Change View

About This Item

Linear Formula:

CH₃CH₂C(CH₃)₂OK

CAS Number:

41233-93-6

Molecular Weight:

126.24

UNSPSC Code:

12352001

NACRES:

NA.22

PubChem Substance ID:

329762401

MDL number:

MFCD00064808

Beilstein/REAXYS Number:

4149025

Concentration:

2 M in THF

Form:

liquid

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

form

liquid

Quality Level

100

concentration

2 M in THF

density

0.920 g/mL at 25 °C

SMILES string

[K+].CCC(C)(C)[O-]

InChI

1S/C5H11O.K/c1-4-5(2,3)6;/h4H2,1-3H3;/q-1;+1

InChI key

ZRLVQFQTCMUIRM-UHFFFAOYSA-N

Description

General description

Potassiumtert-pentoxide solution is a strong and sterically hindered alkoxide baseprepared by treating oil-free potassium hydride with anhydrous t-pentylalcohol in anhydrous solvent.

Application

Potassium tert-pentoxide solution can be used as a base in the:

Wittig reaction of ketoesters with methyltriphenylphosphonium bromide to synthesize alkenes.
Palladium-catalyzed Buchwald-Hartwig amination reaction.

It can also be used:

To prepare potassium tert-pentoxide-crown ether complexes, which is used as a Lewis base catalyst in Mukaiyama aldol reaction.
As an activator for (difluoromethyl)trimethylsilane to generate difluoromethyl-carbanion which reacts with isothiocyanate to synthesize α, α-difluoromethyl thioamide.

Features and Benefits

In the absence of air and moisture, potassium tert-pentoxide solutions in benzene or toluene may be stored in a refrigerator for up to 1 year without significant deterioration.