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Merck
CN

73469

(SP,S′P)-1,1′-Bis[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-2,2′-bis[(R)-α-(dimethylamino)benzyl]ferrocene

≥97%

Synonym(s):

(1R,1′R)- 1,1′-Bis[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-2,2′-bis[(R)-(dimethylamino)phenylmethyl]ferrocene (acc to CAS), Mandyphos SL-M004-1

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About This Item

Empirical Formula (Hill Notation):
C64H74FeN2O4P2
CAS Number:
Molecular Weight:
1053.08
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352005
MDL number:
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Quality Level

assay

≥97%

form

powder

optical purity

ee: ≥99%

functional group

amine, phenyl, phosphine

SMILES string

[Fe].COc1c(C)cc(cc1C)P([C]2[CH][CH][CH][C]2[C@H](N(C)C)c3ccccc3)c4cc(C)c(OC)c(C)c4.COc5c(C)cc(cc5C)P([C]6[CH][CH][CH][C]6[C@H](N(C)C)c7ccccc7)c8cc(C)c(OC)c(C)c8

InChI

1S/2C32H37NO2P.Fe/c2*1-21-17-26(18-22(2)31(21)34-7)36(27-19-23(3)32(35-8)24(4)20-27)29-16-12-15-28(29)30(33(5)6)25-13-10-9-11-14-25;/h2*9-20,30H,1-8H3;/t2*30-;/m11./s1

InChI key

HEJIDMKBSDYNOY-LJXMUBMNSA-N

General description

Mandyphos SL-M004-1 is a chiral ferrocenyl based diphosphine ligand belonging to the Mandyphos family.

Application

It may be used as a chiral ligand in the rhodium complex-catalyzed hydrogenation reaction, a key step during the synthesis of argatroban.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

sold in collaboration with Solvias AG


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Modular chiral ligands: the profiling of the Mandyphos and Taniaphos ligand families.
Spindler F, et al.
Tetrahedron Asymmetry, 15(14), 2299-2306 (2004)
Diastereoselective synthesis of an argatroban intermediate, ethyl (2R, 4R)-4-methylpipecolate, by means of a Mandyphos/rhodium complex-catalyzed hydrogenation.
Ferraboschi P, et al.
Tetrahedron Asymmetry, 22(16), 1626-1631 (2011)



Global Trade Item Number

SKUGTIN
73469-100G04061832625836
73469-100MG04061832625843
73469-1G04061826084052
73469-250G04061832625850
73469-50G04061832625874
73469-5G04061832625881
73469-500MG04061832625867