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763896

DL-α-Tocopherol methoxypolyethylene glycol succinate

greener alternative

Greener Alternative

powder

Synonym(s):

Polyethylene glycol, TPGS-750-M

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About This Item

CAS Number:
1309573-60-1
MDL number:
MFCD00146616
NACRES:
NA.22
UNSPSC Code:
51171641
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Product Name

DL-α-Tocopherol methoxypolyethylene glycol succinate,

form

powder

Quality Segment

100

reaction suitability

reagent type: catalyst
reaction type: C-H Activation, reagent type: surfactant

greener alternative product characteristics

Catalysis
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

transition temp

Tm 29-34

greener alternative category

, Aligned

General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product TPGS-750-M is a lead surfactant for many transition metal-catalyzed cross-couplings and has been enhanced for catalytic efficiency. Find details here.
Learn More at the Professor and Product Portal of Professor Bruce Lipshutz.

Application

DL-α-Tocopherol methoxypolyethylene glycol succinate (TPGS-750-M), a biodegradable and water-soluble derivative of natural vitamin E, is used as an environmentally benign nonionic surfactant in metal-catalyzed cross-coupling reactions in water. It is used in Heck, Suzuki-Miyaura, Sonogashira, and Negishi like couplings reactions. It can also be utilized in aminations, C-H activations, and olefin metathesis reactions.
TPGS-750-M can also be employed in:
  • The nucleophilic aromatic substitution reaction of aryl and heteroaryl halides with nitrogen, oxygen, and sulfur nucleophiles under mild conditions.
  • The preparation of quinoxaline-2,3 diones from quinoxalinones via C(sp2)-H hydroxylation reaction.
  • The intramolecular N-arylation of amines using a copper catalyst.

On the Way Towards Greener Transition-Metal-Catalyzed Processes as Quantified by E Factors

Other Notes

Watch Professor Lipshutz talk about TPGS-750-M in this webinar:
From milligrams to kilograms: synthetic chemistry following nature′s lead

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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