form
pellets
mol wt
PDLLA average Mn 2,000, PEG average Mn 2,000, average Mn 4,000 (total)
degradation timeframe
2-5 weeks
transition temp
Tm 29-33 °C
PDI
<1.1 (typical PEG), <1.2, <1.3 (overall)
storage temp.
2-8°C
General description
Block copolymer micelles are widely used in drug delivery applications. PEG-PDLLA is a biodegradable polymeric micelle which is used as a carrier for hydrophobic drugs like Paclitaxel. The hydrophilic PEG and hydrophobic PDLLA form the micelle core wherein the hydrophobic drug is loaded. The incorporation of the 10-alkyl end cap (decane) increases the hydrophobicity of the micelle core and increases its solubilizing capability for hydrophobic drugs.†
Application
Used as a carrier for the controlled and targeted release of anticancer hydrophobic drugs.
Features and Benefits
- Good biocompatibility, low immunogenicity and good degradability.
- Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
>230.0 °F
flash_point_c
> 110 °C