form
pellets
mol wt
PDLLA average Mn 2,000, PEG average Mn 2,000, average Mn 4,000 (total)
degradation timeframe
2-5 weeks
transition temp
Tm 29-33 °C
PDI
<1.1 (typical PEG), <1.2, <1.3 (overall)
storage temp.
2-8°C
General description
Block copolymer micelles are widely used in drug delivery applications. PEG-PDLLA is a biodegradable polymeric micelle which is used as a carrier for hydrophobic drugs like Paclitaxel. The hydrophilic PEG and hydrophobic PDLLA form the micelle core wherein the hydrophobic drug is loaded. The incorporation of the 10-alkyl end cap (decane) increases the hydrophobicity of the micelle core and increases its solubilizing capability for hydrophobic drugs.†
Application
Used as a carrier for the controlled and targeted release of anticancer hydrophobic drugs.
Features and Benefits
- Good biocompatibility, low immunogenicity and good degradability.
- Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
>230.0 °F
flash_point_c
> 110 °C
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Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.
AliAliphatic polyesters, including polylactide and polyglycolide, are biodegradable polymers widely used in medical applications.
The development of drugs that target specific locations within the human body remains one of the greatest challenges in biomedicine today.
Hongtao Chen et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(18), 6596-6601 (2008-05-01)
It is generally assumed that polymeric micelles, upon administration into the blood stream, carry drug molecules until they are taken up into cells followed by intracellular release. The current work revisits this conventional wisdom. The study using dual-labeled micelles containing
Arunvel Kailasan et al.
Acta biomaterialia, 6(3), 1131-1139 (2009-09-01)
This work describes the synthesis and characterization of novel thermoresponsive highly branched polyamidoamine-polyethylene glycol-poly(D,L-lactide) (PAMAM-PEG-PDLLA) core-shell nanoparticles. A series of dendritic PEG-PDLLA nanoparticles were synthesized through conjugation of PEG of various chain lengths (1500, 6000 and 12,000 g mol(-1)) to
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| 货号 | GTIN |
|---|---|
| 764736-1G | 04061826646465 |