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764779

Poly(ethylene glycol) methyl ether-block-poly(D,L lactide)

PEG average Mn 2,000, PDLLA average Mn 2,000

Synonym(s):

PEG-PDLLA

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About This Item

NACRES:
NA.23
UNSPSC Code:
12162002
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Quality Segment

description

n=45, m=28 (typical), typical PEG PDI<1.1; overall PDI<1.4 (THF, PEO)

form

pellets

mol wt

PDLLA average Mn 2,000, PEG average Mn 2,000, average Mn 4,000 (total)

degradation timeframe

2-4 weeks

transition temp

Tg 11 °C (PEG block), Tm 244-248 °C, Tg 88 °C (PDLLA block)

PDI

≤1.4

storage temp.

2-8°C

General description

Block copolymer micelles are widely used in drug delivery applications. PEG-PDLLA is a biodegradable polymeric micelle which is used as carriers for hydrophobic drugs like paclitaxel. PEG is the hydrophilic part and PDLLA is the hydrophobic part which forms the micelle core wherein the hydrophobic drug is loaded.

Application

Used as a carrier for the controlled and targeted release of anticancer hydrophobic drugs.
water-solubilization of drugs

Features and Benefits

  • Good biocompatibility, low immunogenicity and good degradability.
  • Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.

Legal Information

Product of AKINA, Inc.

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Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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