764779
Poly(ethylene glycol) methyl ether-block-poly(D,L lactide)
PEG average Mn 2,000, PDLLA average Mn 2,000
Synonym(s):
PEG-PDLLA
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About This Item
NACRES:
NA.23
UNSPSC Code:
12162002
Quality Segment
description
n=45, m=28 (typical), typical PEG PDI<1.1; overall PDI<1.4 (THF, PEO)
form
pellets
mol wt
PDLLA average Mn 2,000, PEG average Mn 2,000, average Mn 4,000 (total)
degradation timeframe
2-4 weeks
transition temp
Tg 11 °C (PEG block), Tm 244-248 °C, Tg 88 °C (PDLLA block)
PDI
≤1.4
storage temp.
2-8°C
General description
Block copolymer micelles are widely used in drug delivery applications. PEG-PDLLA is a biodegradable polymeric micelle which is used as carriers for hydrophobic drugs like paclitaxel. PEG is the hydrophilic part and PDLLA is the hydrophobic part which forms the micelle core wherein the hydrophobic drug is loaded.
Application
Used as a carrier for the controlled and targeted release of anticancer hydrophobic drugs.
water-solubilization of drugs
Features and Benefits
- Good biocompatibility, low immunogenicity and good degradability.
- Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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