764787
Poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide)
average Mn (1,000-1,000-1,000), lactide:glycolide 50:50
Synonym(s):
PLGA-PEG-PLGA
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About This Item
NACRES:
NA.23
UNSPSC Code:
12162002
description
typical PEG PDI<1.1; overall PDI<1.2 (THF, PEO)
form
liquid
feed ratio
lactide:glycolide 50:50
mol wt
PEG average Mn 1,000, PLGA average Mn 2000, average Mn (1,000-1,000-1,000)
degradation timeframe
1-2 weeks
PDI
<1.2
storage temp.
2-8°C
General description
PLGA-PEG-PLGA is an amphiphilic triblock copolymer which can self-assemble into micelles in aqueous medium due to the hydrophobic interactions present in the hydrophobic segments. The PEG segment imparts hydrophilicity and improves the biocompatibility of the copolymer. The PLGA segment forms a hydrophobic core and can solubilize hydrophobic drugs. These copolymers are widely used as nanocarriers for the sustained release of drugs.
Application
Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.
Features and Benefits
Biocompatible, degradable, thermosensitive, high stability, small size (<200 nm) and properties can be easily modified.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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