765139
Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)
PEG average Mn 5,000, PLGA Mn 7,000
Synonym(s):
PEG-PLGA, Polyethylene glycol, mPEG-b-PLGA
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About This Item
Linear Formula:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
NACRES:
NA.23
UNSPSC Code:
12162002
form
solid
Quality Segment
feed ratio
lactide:glycolide 50:50
mol wt
PEG average Mn 5,000, PLGA Mn 7,000, average Mn 12,000 (total)
degradation timeframe
1-4 weeks
transition temp
Tg 24 °C, Tm 38-43 °C
PDI
<2.0
storage temp.
2-8°C
General description
Amphiphilic block copolymers (AmBC) are made up of two chemically different homopolymer blocks. One of the block is hydrophilic and the other one is hydrophobic. These macromolecules have the properties to self-assemble when dissolved in an aqueous media. PEG-PLGA is one the most commonly used biodegradable amphiphilic block copolymers for drug delivery applications. PEG is the hydrophilic part and PLGA is the hydrophobic part.
Application
Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.
forming "stealth" pegylated microparticles
Features and Benefits
- Good biocompatibility, low immunogenicity and good degradability.
- Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
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