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Merck
CN

766577

Poly(L-lactide) 2-hydroxyethyl, methacrylate terminated

average Mn 5,500, PDI ≤1.2

Synonym(s):

PLA methacrylate, PLLA MA terminated, PLLA vinyl end group

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About This Item

Linear Formula:
C6H10O3(C6H8O4)n
NACRES:
NA.23
UNSPSC Code:
12162002
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form

powder or crystals

optical activity

[α]22/D -144°, c = 0.5% in chloroform

mol wt

average Mn 5,500

PDI

≤1.2

storage temp.

2-8°C

General description

The copolymers are biocompatible and non toxic in nature. These functional polymers belong to a class of biodegradable polymer.

Application

Drug Delivery including coating nanoparticles;end-group functionalization; macroinitiator or block precursor. It may also be used in implant material for bone fixation, surgical sutures, tissue engineering.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Miscibility and phase structure of binary blends of polylactide and poly(methyl methacrylate)
Zhang G, et al
Journal of Polymer Science. Part B, Polymer Physics, 1, 23-30 (2003)
Wolf, Florian F.; et al.
Macromolecules, 42, 5622-5628 (2009)
Zhang, Wen-Bin; et al.
Macromolecules, 44, 2589-2596 (2011)
Preparation of Protein-Loaded Poly(L-Lactide) Microspheres by Solution-Enhanced Dispersion by Supercritical CO2
Chen A Z, et al.
Journal of Biomimetics, Biomaterials, and Tissue Engineering, 11, 93-100 (2011)

Articles

In the past two decades, tissue engineering and regenerative medicine have become important interdisciplinary fields that span biology, chemistry, engineering, and medicine.

Innovations in polymer technology have had a significant impact on the advancement of novel drug delivery systems.

Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.

Microparticles in drug delivery: Study on controlling chitosan microparticle size and distribution, exploring encapsulation of BSA and TPP cross-linker.

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